# SU:M37 Losec Summa Elixir Night Ampoule for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [SU:M37](https://lovi.care/skincare/it/brands/su-m37)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your normal skin, as glycerin and panthenol provide essential hydration and support barrier function, though it lacks sufficient emollients for complete nourishment.
- The formulation provides general skincare benefits like hydration and soothing, which are supportive but not directly targeted at your pigmentation concerns due to the absence of ingredients like Vitamin C or Niacinamide.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/su-m37/losec-summa-elixir-night-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Lactobacillus Soybean Extract Ferment, Panthenol, Gold, Wine Extract, Beta-Glucan

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- ANT1 soybean extract cream ameliorated complications and enhanced skin recovery after Nd:YAG laser therapy in 45 Asian women, with higher concentrations significantly reducing wrinkles, spots, and pores compared to placebo. ([Annals of Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29369914/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A phytoestrogen-enriched cosmetic formulation containing biotransformed soybean extract increased collagen-I expression in fibroblast cells and skin explants in an estrogen receptor beta-dependent manner without harming skin microbiota. ([Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas, 2023](https://pubmed.ncbi.nlm.nih.gov/37878883/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topically delivered gold-coated silica microparticles combined with laser pulses reduced inflammatory lesions compared with sham treatments in patients with moderate-to-severe facial acne. ([The Journal of Investigative Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25748556/))
- Laser-activated gold microparticles combined with topical retinoids reduced inflammatory lesion counts by 68% at month 12 in 52 patients with mild-to-moderate inflammatory facial acne. ([Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37943275/))
- Combined treatment with a micro-diamond and micro-gold topical serum and a 1064 nm picosecond Nd:YAG laser produced moderate clinical improvement and high participant satisfaction in 40% of participants for facial skin rejuvenation with minimal side effects. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/35304935/))
- Treatment with Jacquez grapes wine extract protected a three-dimensional tissue culture model of human epidermis against UVB-induced oxidative damage by preventing ROS-mediated alterations. ([Toxicology in Vitro, 2006](https://pubmed.ncbi.nlm.nih.gov/16901675/))
- The V. vinifera skin extract (ACH37) scavenged reactive oxygen species, prevented inflammation, modulated extracellular matrix remodeling, increased telomere length and telomerase activity, and reversed UV-induced gene suppression in in vitro and ex vivo assays. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37464908/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))

## Why other moisturizers fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss. ([Acta Biochimica Polonica, 2012](https://pubmed.ncbi.nlm.nih.gov/22428137/))
- Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/))

## What reviewers say

Based on limited data, this night ampoule is highly rated for providing intensive hydration and a radiant glow, particularly for dry or mature skin. Users appreciate its luxurious texture and skin barrier repair benefits. However, the high price point and the presence of essential oils and alcohol are noted concerns, with some experiencing a heavy finish or availability issues.

- Liked: Intensive hydration (mostly mentioned)
- Liked: Radiance and glow (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Luxurious texture (sometimes noted)
- Liked: Skin barrier repair (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritants (sometimes noted)
- Disliked: Heavy/sticky finish (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does SU:M37 Losec Summa Elixir Night Ampoule work for skin with dark spots?

SU:M37 Losec Summa Elixir Night Ampoule works moderately well for skin with dark spots, as it provides essential hydration and soothing benefits but lacks targeted ingredients like Vitamin C or Niacinamide for dark spots. To better care for skin with dark spots, a product of this type needs effective ingredients for pigmentation, such as niacinamide and brightening agents, along with strong barrier support and antioxidant protection without any risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum does not actually include targeted dark spot ingredients like Vitamin C or niacinamide, but it provides helpful hydration and soothing benefits through ingredients like glycerin and panthenol. A product of this type needs effective brightening ingredients like niacinamide and vitamin C, alongside hydrating agents and soothing plant extracts, to properly care for skin with dark spots.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Lactobacillus Soybean Extract Ferment do for skin with dark spots?

Lactobacillus Soybean Extract Ferment helps make dark spots less noticeable and evens out skin tone. It may slow down the extra pigment production that leads to dark patches, making your skin look brighter and clearer.

### What does Panthenol do for skin with dark spots?

Panthenol helps moisturize dry skin and calms irritation, but it is not known to directly fade dark spots. To effectively target dark spots, this skin type needs brightening ingredients like niacinamide or vitamin C.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. A product of this type needs brightening ingredients like vitamin C or niacinamide to effectively target dark spots.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol step to help calm and hydrate your skin. This product of this type works best for skin with dark spots when it includes targeted brighteners like Vitamin C or Niacinamide.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this moisturizing treatment in the evening as part of your routine. This type of product needs targeted brightening ingredients like Vitamin C or Niacinamide and rich softeners to effectively care for skin with dark spots.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This moisturizing treatment is unlikely to cause breakouts or clogging for skin with dark spots, as its safety profile is excellent and it lacks harsh ingredients. However, to effectively address dark spots, this type of skin needs targeted ingredients like Vitamin C or Niacinamide along with sufficient emollients.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is safe to use around the eyes and on the body because it has an excellent safety profile with no harsh ingredients. To properly care for skin with dark spots, this type of product needs targeted brightening ingredients like Vitamin C or Niacinamide along with richer softening agents.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for skin with dark spots

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/it/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dark-spots) — High fit — €103.95 at Amazon
- [SkinCeuticals Hydrating B5 Gel](https://lovi.care/skincare/it/p/skinceuticals/hydrating-b5-gel/for/dark-spots) — High fit — €80.96 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dark-spots) — High fit — €21.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — €20.40 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Propanediol, Alcohol Denat, 1,2-Hexanediol, Butylene Glycol, Lactobacillus Soybean Extract Ferment, Chondrus Crispus Extract, Bis-Peg-18 Methyl Ether Dimethyl Silane, Panthenol, Peg-40 Hydrogenated Castor Oil, Saccharomyces Barley Seed Ferment Filtrate, Saccharomyces Potato Extract Ferment Filtrate, Lauryl Dimethicone Polyglycerin-3 Crosspolymer, Polymethylsilsesquioxane, Tromethamine, Glyceryl Acrylate Acrylic Acid Copolymer, Wine Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polyquaternium-51, Gold, Euterpe Oleracea Fruit Extract, Vinegar, Bergamot Oil Fruit, Sodium Polyacrylate, Adenosine, Blueberry Fruit Extract, Lactobacillus Pear Juice Ferment Filtrate, Grapefruit Peel Oil, Lactobacillus Wasabia Japonica Extract Root Ferment, Saccharomyces Grape Extract Ferment, Lactobacillus Water Hyacinth Ferment, Lactobacillus Ginseng Root Ferment Filtrate, Lactobacillus Rye Flour Ferment, Saccharomyces Xylinum Black Tea Ferment, Monascus Rice Ferment, Trisodium Edta, Carthamus Tinctorius Flower Extract, Rosa Damascena Oil Flower, Phyllanthus Emblica Fruit Extract, Artemisia Annua Extract, Neem Leaf Extract, Beta-Glucan, Camellia Sinensis Leaf Extract, Elettaria Cardamomum Seed Oil, Cananga Odorata Oil Flower, Lavandula Angustifolia Oil Lavender Oil, Caprylic Capric Triglyceride, Pogostemon Cablin Oil, Salvia Officinalis Leaf Extract, Zingiber Officinale Root Extract, Clove Flower Extract, Yeast Extract Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Diospyros Kaki Fruit Extract, Cucumis Sativus Fruit Extract, Melissa Officinalis Extract, Brassica Oleracea Capitata Leaf Extract, Rehmannia Glutinosa Root Extract, Morus Bombycis Leaf Extract, Ficus Carica Fruit Extract, Perilla Frutescens Leaf Extract, Geranium Robertianum Extract, Ipomoea Batatas Root Extract, Acorus Calamus Root Extract, Undaria Pinnatifida Extract, Pyrus Malus Fruit Extract, Leuconostoc Radish Root Extract, Fraxinus Excelsior Leaf Extract, Brassica Rapa Leaf Extract Turnip Leaf Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Nelumbo Nucifera Root Extract, Thymus Vulgaris Leaf Extract, Onion Bulb Extract, Portulaca Oleracea Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Codonopsis Lanceolata Root Extract, Ginkgo Biloba Nut Extract, Lavandula Angustifolia Flower Extract Lavender Flower Extract, Sesamum Indicum Seed Extract, Citrus Unshiu Peel Extract, Grifola Frondosa Fruiting Body Extract, Fennel Fruit Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Parsley Extract, Platycodon Grandiflorum Root Extract, Watermelon Fruit Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Eriobotrya Japonica Leaf Extract, Houttuynia Cordata Extract, Ocimum Basilicum Leaf Extract, Artemisia Princeps Leaf Extract, Panicum Miliaceum Seed Extract, Sasa Veitchii Leaf Extract, Acer Palmatum Leaf Extract, Glechoma Hederacea Extract, Schizonepeta Tenuifolia Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Anemarrhena Asphodeloides Root Extract, Equisetum Arvense Extract, Spinach Leaf Extract, Cassia Obtusifolia Seed Extract, Centella Asiatica Extract, Dandelion Leaf Extract, Camellia Japonica Leaf Extract, Trichosanthes Kirilowii Root Extract, Lycium Chinense Fruit Extract, Allium Sativum Bulb Extract, Illicium Verum Fruit Extract Anise Fruit Extract, Prunus Armeniaca Fruit Extract Apricot Fruit Extract, Citrus Junos Fruit Extract, Beta Vulgaris Root Extract, Musa Sapientum Fruit Extract, Rubus Idaeus Fruit Extract Raspberry Fruit Extract, Carica Papaya Fruit Extract, Phaseolus Angularis Seed Extract, Hemerocallis Fulva Flower Extract, Hypericum Perforatum Stem Extract Flower Leaf, Curcuma Longa Root Extract, Coriandrum Sativum Leaf Extract Fruit, Helianthus Annuus Seed Extract Sunflower Seed Extract, Nigella Sativa Seed Extract, Lentinus Edodes Extract, Cymbopogon Citratus Extract, Plantago Major Seed Extract, Marrubium Vulgare Extract, Cichorium Intybus Root Extract, Prunus Persica Fruit Extract, Peppermint Stem Extract Flower Leaf, Chaenomeles Sinensis Fruit Extract, Bergamot Leaf Extract, Lippia Citriodora Leaf Extract, Akebia Quinata Extract, Crataegus Cuneata Fruit Extract, Actinidia Polygama Fruit Extract, Prunus Salicina Fruit Extract, Jasminum Sambac Flower Extract Jasmine Flower Extract, Citrus Aurantium Dulcis Oil Flower, Cinnamomum Zeylanicum Bark Extract, Valeriana Officinalis Root Extract Rhizome, Honey Extract, Boswellia Serrata Extract Resin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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