SkinMedica TNS Advanced+ Serum for mature skin
Human Fibroblast Conditioned Media
Collagen Peptides
Trifluoroacetyl Tripeptide-2
Glycerin
Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract
High
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this serum utilizes Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2 to effectively address wrinkles and fine lines by promoting skin rejuvenation and improving texture.
- Whey protein and Vitis Vinifera flower cell extract further support collagen stimulation and barrier repair, enhancing overall skin health.
- The formula is safe for your skin, containing soothing ingredients like Glycerin and Shea Ethyl Esters Butter with no harsh or prohibited components.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.5Overall rating based on 5.2k+ reviewsBased on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.
Highlights
Improves fine lines Mostly Mentioned
- “can make the world of difference in your fine lines and wrinkles”
- “deeper lines around my mouth lessened significantly”
- “notice an improvement in fines lines”
- “creases in my forehead became more shallow”
Very expensive price Mostly Mentioned
- “The price tag is steep”
- “Expensive but fast results!”
- “The price is ridiculous”
- “A lot of money for a flawed product”
Firms sagging skin Often Mentioned
- “my skin had much more elasticity”
- “feels firmer, stays well hydrated”
- “preventing/restoring sagging skin”
- “plumps and firms with zero irritation”
Smoothes skin texture Often Mentioned
- “My skin looks smoother”
- “enhanced skin texture and tone”
- “overall glow to my skin”
- “visibly softer skin and improved texture”
Faulty pump dispenser Often Mentioned
- “One of the pumps failed on me”
- “The pumps did not work properly”
- “faulty pump & other issues”
- “dual pump failure issue”
Safe for sensitive skin Sometimes Noted
- “anti aging treatment that works for sensitive skin”
- “enhanced my skin without causing irritation”
- “plumps and firms with zero irritation”
- “Safe for sensitive skin”
Uneven product dispensing Sometimes Noted
- “serum ran out before the cream that you mix it with”
- “never know whether I'm getting enough from each side”
- “only have the clear serum but not the white one coming out”
- “They didn't dispense evenly”
Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more
Questions and answers
What makes SkinMedica TNS Advanced+ Serum a great fit for mature skin?
SkinMedica TNS Advanced+ Serum is a great fit for mature skin because it utilizes human fibroblast conditioned media and trifluoroacetyl tripeptide-2 to smooth wrinkles and fine lines, while whey protein and grape flower cell extract help rebuild collagen and repair the skin barrier. It also includes gentle, soothing ingredients like glycerin that help keep skin soft and comfortable.
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it utilizes Human Fibroblast Conditioned Media, Trifluoroacetyl Tripeptide-2, and collagen peptides to help smooth out wrinkles and fine lines. Ingredients like glycerin and grape flower cell extract further support skin health by keeping it hydrated and protected.
What does Human Fibroblast Conditioned Media do for mature skin?
Human fibroblast conditioned media helps reduce signs of aging and supports skin recovery in mature skin. It may improve fine lines, wrinkles, and overall skin quality, and helps stimulate skin repair after procedures.
Dermatologic Surgery, 2024International Journal of Molecular Sciences, 2019
What do Collagen Peptides do for mature skin?
Collagen peptides help improve skin elasticity, hydration, and the appearance of wrinkles in mature skin with daily use over several weeks. Clinical studies show that this ingredient supports skin firmness by helping boost moisture and structural proteins.
Where does this serum go in a skincare routine for mature skin?
This serum goes in your evening routine, applied after cleansing and toning and right before your moisturizer. Putting this treatment in the evening helps keep your skin safe around sun exposure while working on fine lines and texture.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying your retinol product first and following with this treatment serum. This helps smooth fine lines while minimizing potential irritation when your skin is properly adjusted.
How often should I use this serum?
This serum is used in your evening routine, applying it once a day for simplicity and extra safety around sun exposure. It helps smooth mature skin by targeting wrinkles and fine lines while supporting overall skin health.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains soothing ingredients like glycerin and shea ethyl esters butter with no harsh or heavy components. It helps smooth fine lines and improve texture while keeping your skin calm.
Dermatologic Surgery, 2024Clinical, Cosmetic and Investigational Dermatology, 2017
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures.
Dermatologic Surgery, 2024Grape-derived exosome-like nanoparticles significantly reduce ultraviolet light damage and promote skin repair and regeneration in photoaged skin by modulating epithelial cell proliferation and differentiation.
Journal of Food Science, 2025Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT).
Journal of Photochemistry and Photobiology. B, Biology, 2020A porous functionally graded scaffold based on κ-carrageenan, arginine, and whey protein isolate was designed and developed for the management of chronic skin wounds, with cell migration, adhesion, and proliferation evaluated in vitro on fibroblasts and wound healing potential studied in vivo on a murine model.
International Journal of Pharmaceutics, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Ingredients
Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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