# SkinMedica TNS Advanced+ Serum for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [SkinMedica](https://lovi.care/skincare/it/brands/skinmedica)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry skin due to the presence of Shea Ethyl Esters Butter and Glycerin, which provide emollient and humectant actions respectively, addressing dryness and flakiness.
- The serum offers excellent skin rejuvenation with Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2, improving skin texture and reducing fine lines, while Lactococcus Lysate Ferment and Whey Protein further support skin health.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Human Fibroblast Conditioned Media, Collagen Peptides, Trifluoroacetyl Tripeptide-2, Glycerin, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures. ([Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/))
- A porous functionally graded scaffold based on κ-carrageenan, arginine, and whey protein isolate was designed and developed for the management of chronic skin wounds, with cell migration, adhesion, and proliferation evaluated in vitro on fibroblasts and wound healing potential studied in vivo on a murine model. ([International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38621616/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls. ([Frontiers in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38751975/))
- Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls. ([Journal of Agricultural and Food Chemistry, 2020](https://pubmed.ncbi.nlm.nih.gov/31967468/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.

- Liked: Improves fine lines (mostly mentioned)
- Disliked: Very expensive price (mostly mentioned)
- Liked: Firms sagging skin (often mentioned)
- Liked: Smoothes skin texture (often mentioned)
- Disliked: Faulty pump dispenser (often mentioned)
- Liked: Safe for sensitive skin (sometimes noted)
- Disliked: Uneven product dispensing (sometimes noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SkinMedica TNS Advanced+ Serum a great fit for dry skin?

SkinMedica TNS Advanced+ Serum is a great fit for dry skin because it contains shea ethyl esters butter and glycerin, which help smooth away dryness and flakiness. It also features human fibroblast conditioned media and peptides to rejuvenate skin texture and reduce fine lines without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin thanks to shea ethyl esters butter and glycerin, which soften dry patches and hold moisture in the skin. It is very unlikely to cause irritation and helps improve skin texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Human Fibroblast Conditioned Media do for dry skin?

Human Fibroblast Conditioned Media helps reduce signs of aging and supports skin recovery. For dry skin, this type of product needs added hydrating ingredients and rich emollients to keep the skin soft and smooth.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/), [Photodermatology, Photoimmunology & Photomedicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26577060/)

### What do Collagen Peptides do for dry skin?

Collagen peptides help improve dry skin by boosting hydration and keeping skin soft and smooth over time. Taking them daily helps lock in moisture and supports your skin barrier so it holds onto water better.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/), [Nutrients, 2023](https://pubmed.ncbi.nlm.nih.gov/37432180/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing, following Lovi routines for simpler application and extra safety around sun exposure. It is unlikely to irritate dry skin because it lacks harsh ingredients.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first in your evening routine, letting it absorb before you put on your retinol. This approach helps nourish your dry skin while keeping the risk of irritation low because the formula is gentle.

### How often should I use this serum?

SkinMedica TNS Advanced+ Serum is a great fit for your dry skin and is best used in the evening as part of your routine. Glycerin and shea ethyl esters butter help address dryness and flakiness while keeping the skin safe from irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is a great fit and is unlikely to cause breakouts or clog pores on dry skin because it is free of harsh or heavy ingredients that typically block pores. Its gentle formula hydrates and smooths your skin safely without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €20.29 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/it/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — €48.70 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — €15.16 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinmedica/tns-advanced-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinmedica/tns-advanced-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/skinmedica/tns-advanced-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/skinmedica/tns-advanced-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dry-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/skinmedica/tns-advanced-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/skinmedica/tns-advanced-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/skinmedica/tns-advanced-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinmedica/tns-advanced-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinmedica/tns-advanced-serum/for/dry-skin