# SKIN1004 Probio-Cica Intensive Ampoule for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [SKIN1004](https://lovi.care/skincare/it/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin barrier resilience for your combination skin, as Centella Asiatica Extract and Niacinamide work synergistically to soothe inflammation and control sebum production, addressing your oily shine.
- The formula's inclusion of Butylene Glycol and Glycerin further supports hydration without clogging pores, benefiting your combination skin type.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycerin, Butylene Glycol, Propanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))

## What reviewers say

This ampoule is widely celebrated as a holy grail for repairing damaged skin barriers and soothing irritation, particularly for those with dry, sensitive, or acne-prone skin. Users consistently report a glass skin effect, noting that the milky, viscous texture provides deep hydration and calms redness without leaving a heavy residue. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Barrier repair (often mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle/non-irritating (often mentioned)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Texture heaviness (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin1004 Probio-Cica Intensive Ampoule a great fit for combination skin?

Skin1004 Probio-Cica Intensive Ampoule is a great fit for combination skin because Centella Asiatica Extract and Niacinamide help soothe inflammation and control oily shine while strengthening your skin barrier. Butylene Glycol and Glycerin also support hydration without clogging pores, and the gentle formula is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this ampoule a good fit for combination skin?

Centella Asiatica Extract and Niacinamide make this ampoule a great fit for your combination skin because they soothe inflammation and help control oily shine while strengthening your skin barrier. Glycerin and Butylene Glycol also support lasting hydration without clogging pores, and the formula has a very safe profile that is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Centella Asiatica Extract do for combination skin?

Centella Asiatica Extract helps balance combination skin by boosting moisture levels while keeping redness and irritation calm. It also supports skin barrier repair to help maintain smooth and healthy skin overall.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this ampoule go in a skincare routine for combination skin?

This treatment goes in your evening routine, applied after cleansing and before moisturizing. Putting it in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this ampoule with retinol, and in what order?

Yes, you can use this ampoule with retinol to help calm irritation and keep your skin hydrated. Apply your retinol first, let it absorb, and then follow with this treatment ampoule.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use this ampoule?

This ampoule is used in your evening routine, applying it once a day for simplicity and extra safety around sun exposure. Centella Asiatica Extract and Niacinamide help soothe inflammation and control oily shine without clogging pores, making it a great fit for your combination skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this ampoule clog pores, cause breakouts or purging for combination skin?

This ampoule is unlikely to clog pores or cause breakouts on combination skin because its hydrating ingredients support moisture without heavy oils. Reviewers rarely report breakouts, and the formula is designed to soothe inflammation and control oily shine safely.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €24.75 (https://www.amazon.it/dp/B0CSDMNRGM?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €14.50 (https://www.notino.it/skin1004/madagascar-centella-probio-cica-intensive-ampoule-siero-lenitivo-per-ripristinare-la-barriera-cutanea/p-16210312/)
- Lookfantastic: €22.50 (https://www.lookfantastic.it/p/skin1004-madagascar-centella-probio-cica-intensive-ampoule-50ml/16858551/)
Prices checked 17 Oct – 2 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Propanediol, Caprylic Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Dipropylene Glycol, Polyglyceryl-4 Isostearate, Kidney Vetch
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin