# SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [SKIN1004](https://lovi.care/skincare/it/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry skin as Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP work synergistically to enhance skin barrier resilience and hydration, addressing dryness and flakiness.
- Betaine and Panthenol further support humectant action and soothing effects, complementing the primary barrier-repairing ingredients.
- The formulation is safe for your dry skin, containing no harsh ingredients and featuring soothing components like Centella Asiatica Extract and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Allantoin, Panthenol

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- A combination serum containing galactomyces ferment filtrate, dexpanthenol, and Centella asiatica effectively treated post-acne hyperpigmentation in subjects with colored skin by significantly increasing lightness scores in Fitzpatrick skin type V and reducing the melanin index in Fitzpatrick skin type IV compared to placebo. ([Skinmed, 2021](https://pubmed.ncbi.nlm.nih.gov/33938432/))

## What reviewers say

This ampoule is widely celebrated for repairing damaged skin barriers and soothing irritation, particularly for dry, sensitive, or mature skin types. Users consistently praise its rich, milky texture that provides deep hydration and a radiant glow without a sticky residue. However, it is often deemed too heavy for oily skin or humid weather. This summary is based on a very large amount of data and should be definitely taken into account.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Deeply moisturizing (often mentioned)
- Liked: Luxurious texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Too heavy (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Dropper issues (rarely noted)
- Disliked: Scent concerns (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SKIN1004 Probio-cica Intensive Ampoule a great fit for dry skin?

This treatment is a great fit for your dry skin because Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP work together to help repair the skin barrier and boost lasting hydration. Additional ingredients like Betaine and Panthenol bring extra soothing moisture to keep flaky skin feeling soft and smooth.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for dry skin?

Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP make this serum a great fit by strengthening the skin barrier and boosting hydration to tackle dryness and flakiness. Betaine and Panthenol help by drawing in moisture and keeping your skin calm.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### What does Lactobacillus do for dry skin?

Lactobacillus helps keep dry skin calm and hydrated by supporting the skin barrier and reducing irritation and inflammation. Topical products and lysates containing these bacteria may improve moisture levels and protect against damage, though more support is often needed from richer ingredients like ceramides or hyaluronic acid to fully relieve very dry skin.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31480681/), [Biochemical Society Transactions, 2021](https://pubmed.ncbi.nlm.nih.gov/33704415/)

### What does Centella Asiatica Extract do for dry skin?

Centella asiatica extract helps dry skin by boosting moisture and reducing water loss while calming irritation. It supports barrier repair to keep the skin feeling soft and smooth.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in your evening routine after cleansing and before your moisturizer. Putting it in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment after your retinol or by alternating nights to keep your dry skin calm and comfortable. This pairing helps maintain hydration and supports your skin barrier while you use active ingredients.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### How often should I use this serum?

This treatment is meant for your evening routine, used after cleansing and before moisturizing. You may use it every night since it is safe and gentle for dry skin, helping to keep it calm and hydrated.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

Breakouts from this treatment are unlikely for dry skin since it contains no harsh ingredients and features soothing components. Some reviewers do mention it feels a bit heavy, so use a small amount if your skin easily feels overwhelmed by rich layers.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €20.29 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/it/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — €48.70 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — €15.16 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon

## Where to buy

- Amazon.it: €18.04 (https://www.amazon.it/dp/B0BTRWGQNV?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €14.50 (https://www.notino.it/skin1004/madagascar-centella-probio-cica-intensive-ampoule-siero-lenitivo-per-ripristinare-la-barriera-cutanea/p-16210312/)
- Lookfantastic: €22.50 (https://www.lookfantastic.it/p/skin1004-madagascar-centella-probio-cica-intensive-ampoule-50ml/16858551/)
Prices checked 11 Oct – 6 Nov 2026.

## Ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Polyhydroxystearic Acid, Betaine, Allantoin, Panthenol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- France: https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin