# S.Nature Aqua Squalane Moisturizing Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [S.Nature](https://lovi.care/skincare/it/brands/s-nature)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by squalane and glycerin, which offer optimal hydration and barrier support, while Acetyl Hexapeptide-8 and Adenosine effectively target wrinkles and fine lines by promoting collagen synthesis and skin elasticity.
- The formula's multiple forms of hyaluronic acid in high concentrations ensure excellent moisturizing and plumping effects, further enhancing the overall benefits for your skin.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Squalane and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Sodium Hyaluronate, Collagen, Arginine, Peptides

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))

## What reviewers say

Based on a very large amount of data, this moisturizer is highly effective at providing deep, lasting hydration with a lightweight, non-sticky feel that absorbs quickly. It is frequently noted for creating a desirable glowy, glass-skin finish and is often praised for its suitability for sensitive skin and as a base for makeup. Some users with oily or acne-prone skin have reported experiencing breakouts or congestion, and a moderate number found the finish too shiny or greasy, particularly in humid conditions. A low number of users felt it was insufficient for very dry winter conditions.

- Liked: Lightweight hydration (mostly mentioned)
- Liked: Non-sticky glow (often mentioned)
- Liked: Soothing for sensitive skin (often mentioned)
- Liked: Good makeup base (sometimes noted)
- Disliked: Too shiny (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Insufficient for winter (rarely noted)
- Disliked: Not FA safe (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes S.Nature Aqua Squalane Cream one of the best fits for mature skin?

This cream is an exceptional fit for mature skin because squalane and glycerin deliver deep moisture and barrier support, while peptides and adenosine help smooth out wrinkles and fine lines. Its multiple forms of hyaluronic acid also work to plump the skin, and soothing ingredients like panthenol ensure a very gentle experience with no risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this cream a good fit for mature skin?

Squalane and glycerin make this cream a great fit for mature skin by providing deep hydration and barrier support, while Acetyl Hexapeptide-8 and adenosine help smooth out wrinkles and fine lines. Additionally, multiple forms of hyaluronic acid plump the skin and enhance overall firmness with a very low risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes into both your morning and evening skincare routines as your daily moisturizer step. It helps keep your skin soft and hydrated while targeting fine lines with peptides and adenosine.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first, letting it absorb, and then following with this moisturizer to help keep your skin calm and hydrated. Using a barrier-supporting moisturizer alongside retinol is unlikely to cause irritation and may help your skin better adjust to the treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and smooth. Regular daily application helps improve fine lines, wrinkles, and overall skin texture while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts for mature skin, as it has a very safe profile with gentle ingredients like squalane and panthenol. Reviewers rarely mention breakouts, though a few find it a bit too shiny.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its ingredients are very gentle on thin skin. Regular application of a cream with hyaluronic acid and peptides helps smooth fine lines in the eye area while keeping the skin soft.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/it/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €82.99 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/mature-skin) — Superior fit — €12.09 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €18.06 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €33.99 (https://www.amazon.it/dp/B0B8S9RLPL?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Squalane, Glycerin, 2-Hexanediol, Betaine, Panthenol, Sodium Hyaluronate, Hydrolyzed Collagen, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Adenosine, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Arginine, Allantoin, Xylitylglucoside, Anhydroxylitol, Xylitol, Glucose, Butylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/s-nature/aqua-squalane-moisturizing-cream/for/mature-skin