Rodan + Fields Intensive Renewing Serum for mature skin

How to apply

Questions and answers

What the research says

• Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.

  Journal of Cosmetic Dermatology, 2018

• Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.

  Dermatology, 2002

• Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.

  Dermatology, 1999

• Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question.

  The Journal of Clinical and Aesthetic Dermatology, 2021

• A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women.

  The British Journal of Dermatology, 2010

• A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.

  International Journal of Cosmetic Science, 2024

• Treatment with 2% bis-ethylhexyl hydroxydimethoxy benzylmalonate (HDBM) resulted in a significant reduction of sebum excretion and efficacy against inflamed/red lesions compared to placebo in 44 test subjects with blemished skin over 8 weeks.

  Clinical, Cosmetic and Investigational Dermatology, 2012

• The combination of botulinum toxin and calcium hydroxylapatite applied together produced higher and earlier satisfaction rates and improved hydration in the lower face and neck region compared to calcium hydroxylapatite alone in 15 participants.

  Clinical, Cosmetic and Investigational Dermatology, 2023

• Topically applied calcium hydroxylapatite successfully penetrated fractional laser-induced skin defects and remained in the healing skin for at least six weeks, inducing collagen production around the microspheres in a human volunteer.

  Lasers in Surgery and Medicine, 2025

• Calcium ions from nanophased hydroxyapatite embedded in collagen nanofibers significantly enhanced human dermal fibroblasts, keratinocytes, and hMSCs growth and proliferation, prevented pathogenic bacteria adhesion, enabled hMSCs differentiation, and caused no adverse reaction in rat subcutaneous implantation.

  Nanomedicine, 2021

Ingredients

Bis-Ethylhexyl Hydroxydimethoxy Benzylmalonate, C12-15 Alkyl Benzoate, Cyclopentasiloxane, Dimethicone, Ethoxydiglycol, Ethylhexyl Hydroxystearate, Hydroxyapatite, Palmitoyl Hexapeptide-14, Polysilicone-11, Retinal, Retinyl Palmitate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.