# REJURAN Turnover Ampoule Dual Effect for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [REJURAN](https://lovi.care/skincare/it/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Suitable for normal skin, this product offers excellent moisturizing and plumping effects due to hyaluronic acid and glycerin, which hydrate and support your skin's barrier function with squalane and ceramide NP.
- While beneficial for general hydration and soothing with ingredients like aloe barbadensis leaf juice, it does not specifically target your concerns of wrinkles and fine lines.
- The formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/oily-acne-prone-skin): Average

## Key ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32583541/))
- Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model. ([Photochemistry and Photobiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23711186/))
- Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro. ([Food Research International, 2019](https://pubmed.ncbi.nlm.nih.gov/31108769/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream. ([Acta Poloniae Pharmaceutica, 2011](https://pubmed.ncbi.nlm.nih.gov/21928714/))
- Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention. ([Tissue Barriers, 2022](https://pubmed.ncbi.nlm.nih.gov/34674610/))
- Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials. ([Wounds, 2008](https://pubmed.ncbi.nlm.nih.gov/25941793/))

## What reviewers say

Users frequently report this ampoule delivers a desirable 'glass skin' effect, significantly enhancing hydration, radiance, and skin texture. Many also observe a reduction in fine lines and a strengthened skin barrier. However, some users find the price high for the quantity provided, and a few mention the texture can be too heavy for oily skin types or during warmer months.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glow and radiance (often mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Soothing and repair (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does REJURAN Turnover Ampoule Dual Effect work for mature skin?

This treatment works okay for mature skin, keeping it moisturized and soft with ingredients like hyaluronic acid, glycerin, squalane, and ceramide NP, but it does not specifically target wrinkles and fine lines. A product of this type needs effective anti-wrinkle ingredients that provide relevant skincare benefits to properly address the needs of mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for mature skin?

This moisturizing treatment is an average fit for mature skin because it lacks specific active ingredients to target wrinkles and fine lines, even though hyaluronic acid and glycerin help keep skin hydrated. A product of this type needs effective anti-wrinkle ingredients and skin-repairing nourishers to properly address mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Blackberry Leaf Extract do for mature skin?

Blackberry Leaf Extract helps keep mature skin firm and smooth by protecting the natural elements that give skin its bounce. It also helps calm redness and keeps skin looking fresh as it ages.

### What does Licorice Extract do for mature skin?

Licorice extract helps improve mature skin by fighting cell damage from daily stress, supporting collagen and barrier proteins, and brightening dark spots. It is unlikely to cause irritation and may help smooth and firm dry or aging skin.
Sources: [Journal of Medicinal Food, 2020](https://pubmed.ncbi.nlm.nih.gov/31545123/), [Current Pharmaceutical Design, 2019](https://pubmed.ncbi.nlm.nih.gov/31269882/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though it may also be used in the morning. While it provides good moisture and soothing benefits, mature skin dealing with wrinkles and fine lines needs an option with targeted anti-aging actives like retinoids, peptides, or vitamin C.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying it before your retinol step to help keep your skin comfortable and hydrated. Mature skin needs a product of this type to also include targeted firming ingredients that smooth fine lines and boost elasticity.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. Mature skin needs products with concentrated active ingredients like retinol, peptides, or vitamin C to target wrinkles and fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to cause breakouts or clogged pores for mature skin because its formula avoids harsh or prohibited ingredients that trigger irritation. To better address fine lines and wrinkles on mature skin, this type of product needs targeted anti-aging ingredients like retinol, peptides, or vitamin C.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment safely around the eyes and on the body because the formula is gentle and well-tolerated. However, this product needs targeted anti-aging ingredients like potent botanical extracts and specialized active compounds to properly care for mature skin and reduce wrinkles in delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/it/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €27.55 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/it/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €21.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €64.01 (https://www.amazon.it/dp/B08BZCY3Y1?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- France: https://lovi.care/skincare/fr/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin