# Peter Thomas Roth Peptide 21 Wrinkle Resist Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/it/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Suitable for your normal skin, this serum effectively targets wrinkles with a potent blend of peptides like Tripeptide-10 Citrulline and Acetyl Octapeptide-3, which promote collagen synthesis and plump the skin. While Glycerin and Sodium Hyaluronate offer general hydration, they do not specifically address your primary concern of pigmentation.
- The formulation is safe for your normal skin, as it contains soothing Rosa Centifolia Flower Water and lacks harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Complex Of 21 Peptides, Neuropeptides, Squalane, Sodium Hyaluronate, Ascorbic Acid, Retinyl Palmitate

## What the research says

- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))

## What reviewers say

Users frequently praise this serum for its lightweight, fast-absorbing formula that effectively hydrates and plumps the skin, leading to a visible reduction in fine lines on the forehead and neck. Some users find the product expensive and complain about a sticky residue or a metallic scent.

- Liked: Hydrates and plumps (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Disliked: Sticky residue (sometimes noted)
- Disliked: Metallic scent (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Peter Thomas Roth Peptide 21 Wrinkle Resist Serum a great fit for skin with dark spots?

This serum is a great fit because it contains Ascorbic Acid, a proven brightener that helps fade dark spots, alongside a powerful mix of peptides that plump the skin and smooth lines. Its gentle formula also keeps skin calm and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Which ingredients make this serum a good fit for skin with dark spots?

Ascorbic Acid and Retinyl Palmitate make this serum a good fit by helping to brighten dark spots and even out your skin tone. These ingredients work alongside a blend of peptides that smooth the skin and help reduce the look of fine lines.

### What does Peptide Complex do for skin with dark spots?

Peptide complex helps fade dark spots and brightens uneven skin tone while smoothing fine lines. It improves overall skin texture without causing irritation or sensitivity.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39761149/)

### What do Neuropeptides do for skin with dark spots?

Neuropeptides like calcitonin gene-related peptide and substance P may help reduce dark spots by working together to decrease tyrosinase activity and melanin biosynthesis. This targeted action helps fade uneven pigment and leaves skin looking clearer and more even.
Sources: [Cytokine, 2015](https://pubmed.ncbi.nlm.nih.gov/25982845/)

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in the evening routine as a treatment step after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and offers extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum in your evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation when paired with retinol because the formula contains soothing ingredients.

### How often should I use this serum?

You can use this serum in the evening as part of your routine for skin with dark spots. It is safe for normal skin and helps keep skin smooth while targeting signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts for skin with dark spots because it lacks heavy, pore-clogging ingredients and features a lightweight texture. It does not contain exfoliating acids or retinoids at levels that trigger purging, making it safe for daily use.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/it/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €132.56 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €396.14 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Extract Ferment, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc Radish Root Ferment Filtrate, Peg-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

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- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots
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