# Perricone MD Rejuvenating Moisturizer for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Perricone MD](https://lovi.care/skincare/it/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your normal skin due to glycerin and dimethicone, which hydrate and smooth texture, but it does not specifically target your main goal of pigmentation.
- Tetrahexyldecyl ascorbate and macadamia ternifolia seed oil provide antioxidant activity and nourishment, offering general skincare benefits that are supportive but not optimized for your concerns.
- The product is safe for your normal skin, with no risks of irritation from harsh ingredients and the inclusion of soothing rosemary leaf extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Ribose, Lactic Acid, Macadamia Ternifolia Seed Oil

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))

## Why other moisturizers fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))

## What reviewers say

This moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.

- Liked: Deeply hydrating (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Non-greasy formula (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Product pilling (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)
- Disliked: White cast (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Rejuvenating Moisturizer work for skin with dark spots?

This moisturizer works reasonably well to hydrate and smooth your skin, though it is not specifically designed to fade dark spots. A moisturizing treatment for this skin needs effective brightening ingredients alongside gentle hydrating components to successfully target pigmentation without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for skin with dark spots?

This cream is not an ideal fit for dark spots because it lacks targeted brightening ingredients, though it does include vitamin C and plant oils that offer general nourishment. Skin with dark spots needs effective brightening ingredients alongside soothing and moisturizing components to tackle pigmentation while keeping the skin calm and hydrated.

### What does Acyl-Glutathione do for skin with dark spots?

Acyl-Glutathione helps fade dark spots and brightens your overall skin tone while smoothing out the surface. This ingredient has a safe profile and works by improving pigmentation, though individual results may vary.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Molecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41900080/)

### What does Vitamin C do for skin with dark spots?

Vitamin C helps fade dark spots and brightens uneven skin tone by slowing down pigment production. Daily use also helps calm redness and protects against further sun damage.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/), [Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029672/)

### Where does this cream go in a skincare routine for skin with dark spots?

This moisturizing treatment goes in the morning routine after a hydrating toner and before sunscreen, and in the evening routine after your treatment step. While it helps hydrate and smooth normal skin, it is not optimized for your dark spots, so skin with dark spots needs a dedicated brightening serum containing ingredients like vitamin C or kojic acid.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Journal of Cosmetic and Laser Therapy, 2012](https://pubmed.ncbi.nlm.nih.gov/22401652/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol, applying the retinol first and following with this moisturizer to help keep your skin soft and smooth. This product is safe for your skin with no harsh ingredients, though a moisturizer that specifically targets dark spots with brightening ingredients would work better for your main goal.

### How often should I use this cream?

You can use this moisturizing treatment twice daily to keep your normal skin soft and hydrated. Skin with dark spots needs a dedicated brightening serum containing ingredients like vitamin C or niacinamide to specifically fade discoloration.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for skin with dark spots?

This cream is unlikely to clog pores or cause breakouts on your skin, as it has a safe profile with gentle ingredients and soothing rosemary leaf extract. To better target dark spots, this skin needs dedicated brightening ingredients like vitamin C or niacinamide alongside gentle exfoliants.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it has a safe formula with soothing rosemary leaf extract and gentle hydrators like glycerin that smooth texture. However, skin with dark spots needs a product that specifically targets pigmentation with specialized brightening ingredients.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for skin with dark spots

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/it/p/the-ordinary/natural-moisturizing-factors-ha/for/dark-spots) — High fit — €13.11 at Amazon
- [LANEIGE Water Bank Moisture Cream](https://lovi.care/skincare/it/p/laneige/water-bank-moisture-cream/for/dark-spots) — High fit — €58.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — €20.40 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- France: https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dark-spots (this page)
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
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- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rejuvenating-moisturizer/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rejuvenating-moisturizer/for/dark-spots