# Perricone MD High Potency Retinol Recovery Overnight Moisturizer for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Perricone MD](https://lovi.care/skincare/it/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- This product is highly suitable for your normal skin, as retinol and retinyl linoleate work synergistically to stimulate collagen and repair your skin barrier, while sodium hyaluronate and sodium acetylated hyaluronate provide excellent humectant action.
- The formulation effectively addresses your concerns of wrinkles and fine lines by promoting skin renewal with moderate concentrations of retinol and retinyl linoleate.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like glycerin and sodium hyaluronate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Dmae, Sodium Hyaluronate, Squalane, Ceramide Np

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Retinol Recovery Overnight Moisturizer a great fit for mature skin?

This product is a great fit because it uses retinol and retinyl linoleate to help smooth fine lines and boost collagen, while sodium hyaluronate and glycerin keep your skin hydrated. It has a very safe formula that avoids harsh ingredients, making it gentle on mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit because retinol and retinyl linoleate help smooth fine lines and boost firmness, while sodium hyaluronate keeps your skin hydrated. These ingredients work together to improve the look of mature skin and support its barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does DMAE do for mature skin?

DMAE helps make mature skin feel firmer and smoother while lessening the look of fine lines and wrinkles. Daily use of this ingredient is generally safe and supports a more youthful appearance over time, though it is unlikely to change your skin's basic mechanical properties.
Sources: [American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/), [Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/)

### Where does this cream go in a skincare routine for mature skin?

Apply this treatment in the evening after cleansing and toning, and before your moisturizer. This timing keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying your vitamin C product in the morning and saving this treatment for your evening routine. Using them at different times of day helps you avoid potential irritation while still getting the benefits of both ingredients.

### How often should I use this cream?

Use this treatment in your evening routine, applying it after cleansing and toning. It helps smooth lines and firm mature skin when used consistently as part of your nightly routine.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin. It features a very safe formulation that helps renew the skin without harsh ingredients that typically cause irritation or purging.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment on your body, but avoid applying it too close to the delicate skin directly around your eyes. Mature skin benefits greatly from formulas containing retinol and hydrating ingredients to smooth fine lines, though sensitive areas like the eyelids need much gentler care.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, geraniol, and eugenol). Cetearyl alcohol and behenyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — €22.58 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/it/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — €103.95 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/it/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — €62.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Caprylic Capric Triglyceride, C12-15 Alkyl Benzoate, Propanediol, Shea Ethyl Esters Butter, Dicaprylyl Carbonate, Cetearyl Alcohol, Dimethicone, Squalane, Behenyl Alcohol, Hydrogenated Glycerides, Isoamyl Laurate, Aleurites Moluccana Seed Oil, Glyceryl Stearate, Peg-100 Stearate, Hydrogenated Oil, Hydrogenated Soybean Oil, Ceteareth-20, Glycerin, Phenoxyethanol, Polysilicone-11, Sodium Stearoyl Glutamate, Hydrogenated Olive Oil, Citric Acid, Dimethyl Mea, Petrolatum, Hydrogenated Jojoba Oil, Ethylhexylglycerin, Retinol, Retinyl Linoleate, Xanthan Gum, Polysorbate 20, Parfum, Tetrasodium Glutamate Diacetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Glycine Soja Soybean Lipids, Maltodextrin, Pentylene Glycol, Cetyl Palmitate, Laureth-23, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Nephelium Lappaceum Leaf Extract, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Ceramide Np, Sodium Hydroxide, Trideceth-6 Phosphate, Magnesium Aspartate, Zinc Gluconate, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Magnesium Sulfate, Sodium Hyaluronate Crosspolymer, Phytosterols, Tocopherol, Copper Gluconate, Citronellol, Geraniol, Hydroxycitronellal, Eugenol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/mature-skin
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