Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for oily acne-prone skin
Sodium Hyaluronate
Niacinamide
Squalane
Ceramide Np
Acetyl Glucosamine
High
- HighOily Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for oily acne-prone skin; a few moisturizers fit it even better.
- Journal of Pharmacy & Pharmaceutical Sciences, 2015
- Clinical, Cosmetic and Investigational Dermatology, 2017
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your oily skin, this serum leverages niacinamide for oil control and hydration without greasiness, complemented by acetyl glucosamine to support skin barrier function and address breakouts.
- The high concentrations of sodium hyaluronate and its crosspolymer provide excellent moisturizing benefits, ensuring superior hydration for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like glycerin.
How to apply
- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
People Say
★4.8Overall rating based on 1000+ reviewsUsers consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.
Highlights
Deep hydration Mostly Mentioned
- “Immediate deep hydration”
- “quench dehydrated skin”
- “endlessly hydrated”
- “replenish moisture”
Fast absorbing Often Mentioned
- “Absorbs quickly”
- “sinks in beautifully”
- “non-greasy”
- “no residue”
Plumps fine lines Often Mentioned
- “Plumps wrinkles”
- “softened fine lines”
- “visibly plump”
- “diminish look of lines”
Smooths texture Often Mentioned
- “Skin feels softer”
- “smooth complexion”
- “supple feeling”
- “satin veil”
High price point Often Mentioned
- “Pricey”
- “expensive”
- “splurge”
- “investment”
Gentle on skin Sometimes Noted
- “Lovely on sensitive skin”
- “very healing”
- “no irritation”
- “soothing”
Heavy texture Rarely Noted
- “Not water-like”
- “silicone feel”
- “thicker than expected”
- “too rich”
Packaging issues Rarely Noted
- “Pump broke”
- “hard to dispense”
- “bottle design”
- “product left at bottom”
Scent Rarely Noted
- “Clinical smell”
- “unpleasant scent”
- “strong odor”
- “chemical smell”
Sticky feel Rarely Noted
- “Little sticky”
- “tacky finish”
- “sticky residue”
- “feels heavy”
Sources: lovi.care, perriconemd.com, dermstore.com, lookfantastic.com, ulta.com, lovelyskin.com, and more
Questions and answers
What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum a great fit for oily acne-prone skin?
This serum is a great fit because it uses niacinamide to control oil and hydrate without feeling greasy, while acetyl glucosamine helps support the skin barrier and address breakouts. It also provides deep moisture with sodium hyaluronate and keeps skin calm and safe from irritation thanks to soothing components like glycerin.
Which ingredients make this serum a good fit for oily acne-prone skin?
This serum is a great fit for your oily acne-prone skin because it uses niacinamide to help control oil without feeling greasy and acetyl glucosamine to support your skin barrier and handle breakouts. It also includes sodium hyaluronate to give your skin plenty of moisture without clogging pores.
What does Hyaluronic Acid do for oily acne-prone skin?
Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022
What does Niacinamide do for oily acne-prone skin?
Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024
Where does it go in a skincare routine for oily acne-prone skin?
This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and avoids extra safety concerns around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to keep your skin hydrated and calm, and following it with your retinol. Using a barrier-supporting moisturizer helps reduce the dryness and irritation that often come with retinol use.
How often should I use it?
Use this serum in the evening as part of your routine. Daily application helps keep your skin hydrated and balanced without feeling greasy.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is a great fit for oily acne-prone skin because it uses niacinamide to help control oil without feeling greasy, alongside sodium hyaluronate for lightweight moisture. It is unlikely to cause irritation or breakouts, as it is free of harsh ingredients and includes soothing components.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Pharmacy & Pharmaceutical Sciences, 2015
Can I use it around the eyes or on my body?
You can use this moisturizing treatment around the eyes, as the skin in that area is thin and benefits from gentle hydration. It is safe for the body too, though applying it there may use up the product quickly.
Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019
Ingredients
Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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