# Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Perricone MD](https://lovi.care/skincare/it/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent for your normal skin, this serum effectively addresses wrinkles and fine lines with Acetyl Tetrapeptide-11 and Acetyl Tetrapeptide-9, which promote collagen synthesis and skin elasticity. Niacinamide and Glycerin further support skin health by providing soothing and hydrating benefits.
- The high concentrations of sodium hyaluronate crosspolymer and sodium hyaluronate ensure excellent hydration, plumping the skin and reducing the appearance of fine lines.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Ceramide Np, Acetyl Glucosamine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))

## What reviewers say

Users consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.

- Liked: Deep hydration (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Plumps fine lines (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Hyaluronic Intensive Hydrating Serum one of the best fits for mature skin?

This serum is one of the best fits for mature skin because it uses sodium hyaluronate and its crosspolymer to deliver deep hydration that plumps the skin and softens fine lines. It also includes peptides, niacinamide, and squalane to help smooth wrinkles, boost firmness, and keep the skin feeling soft and healthy.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains acetyl tetrapeptide-11 and acetyl tetrapeptide-9 to boost collagen and firmness, alongside sodium hyaluronate for deep hydration that plumps away fine lines. Niacinamide and glycerin also help soothe the skin and keep it healthy.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing for simplicity and extra safety around sun exposure. It helps smooth fine lines and plump dry or normal mature skin with sodium hyaluronate, peptides, and niacinamide.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol, applying this hydrating treatment first before your retinol to help keep your skin calm and smooth. Using a barrier-supporting product like this alongside retinol is unlikely to cause irritation and may make your skin more comfortable with the treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

This serum is used in the evening as part of your routine for mature skin, applying it once a day for simplicity and extra safety around sun exposure. Daily application helps improve skin moisture, fine lines, and elasticity.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores because it has a light texture and lacks heavy ingredients that trap oil in the skin. Its gentle formulation makes it safe for daily use on mature skin without triggering irritation.

### Can I use this serum around the eyes or on my body?

This serum is safe to use on the thin skin around your eyes and on your body to help smooth and hydrate mature skin. Regular application of these ingredients is unlikely to cause irritation while helping to plump fine lines and improve texture.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/it/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €27.55 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/it/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €21.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €95.00 (https://www.amazon.it/dp/B09WZT5N7X?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin