# Perricone MD Cold Plasma Plus+ Sub-D/Neck for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Perricone MD](https://lovi.care/skincare/it/brands/perricone-md)
Category: [Sunscreens and SPF moisturizers](https://lovi.care/skincare/it/best/sunscreens)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few sunscreens fit it even better.

## Why this fit

- Highly suitable for your normal skin, this formula leverages niacinamide and tetrahexyldecyl ascorbate to provide antioxidant benefits and reduce inflammation, addressing your concerns with redness and irritation.
- The inclusion of ethylhexyl methoxycrylene offers excellent UV protection, further supporting skin health and resilience.
- The product is safe for your sensitive skin, as it contains soothing ingredients like Bisabolol and Niacinamide, and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-acne-prone-skin): High

## Key ingredients

Dmae, Niacinamide, Tetrahexyldecyl Ascorbate, Acetyl Tetrapeptide-9, Glycerin

## What the research says

- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate. ([European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users frequently report visible improvements in skin texture and firmness along the jawline and neck, describing the skin as smoother and more hydrated. A significant number of reviewers consistently complain about a strong, unpleasant scent often compared to pickles or fish, and some experience issues with the product pilling under makeup.

- Disliked: Unpleasant smell (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Visibly tightens and firms (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Lightweight and absorbent (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Pilling or flaking (rarely noted)

## How to apply

- Apply this moisturizing sunscreen AM daily as the final step of your morning routine. Always reapply every two hours when exposed to the sun.
- Apply after your regular moisturizer and before makeup. This product combines hydration and sun protection in one easy step.
- Gently smooth a nickel-sized amount evenly across your face and neck. Avoid rubbing harshly to keep sensitive skin calm.
- Apply the moisturizing sunscreen to clean , dry skin for the best protection. Let it absorb ⏱ fully before stepping outside.
- Avoid direct contact with your eyes. Do a patch test before your first use since your skin is sensitive.
- Video: https://storage.pora.ai/53e9a436d82fca2a189dd08aa21de2fd.mp4

## Questions and answers

### What makes Perricone MD Sub-D/Neck a great fit for sensitive skin?

This product is a great fit because it contains soothing ingredients like bisabolol and niacinamide that help calm redness and irritation. It also lacks harsh or prohibited substances, ensuring a safe and gentle experience for your skin.
Sources: [European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Which ingredients make this cream a good fit for sensitive skin?

This cream is a great fit for sensitive skin because it contains soothing ingredients like bisabolol and niacinamide, along with antioxidants that calm redness and irritation. It also includes safe sun protection to support your skin's health without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### What does DMAE do for sensitive skin?

DMAE may not be the best fit for sensitive skin, because active firming ingredients of this type can sometimes cause irritation and swelling. Sensitive skin needs gentle, soothing ingredients like calming plant extracts and hydrating ceramides to stay soft and smooth without redness.
Sources: [The British Journal of Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17300230/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for sensitive skin?

This moisturizing spf goes in the morning routine as the final step after a cleanser and soothing toner. It helps protect and calm sensitive skin while providing daily UV defense.

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream alongside retinol by applying the moisturizer with SPF in the morning and saving your retinol for your evening routine. This helps protect your sensitive skin while minimizing potential irritation.

### How often should I use this cream?

This moisturizing spf is a great fit for your sensitive skin and is used in the morning step of your routine. Daily application of this type of moisturizing cream helps keep your skin hydrated and protected.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is a great fit for your sensitive skin and is unlikely to cause breakouts, as it features soothing ingredients like bisabolol and niacinamide without harsh substances.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for sensitive skin

- [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/it/p/purito/daily-soft-touch-sunscreen/for/sensitive-skin) — Superior fit — €12.98 at Amazon
- [Eucerin Sun Fluid Anti-Age SPF 50](https://lovi.care/skincare/it/p/eucerin/photoaging-control-sun-fluid-spf-50/for/sensitive-skin) — High fit — €13.45 at Amazon
- [innisfree Daily Sensitive Sunscreen](https://lovi.care/skincare/it/p/innisfree/daily-sensitive-sunscreen/for/sensitive-skin) — High fit — €23.58 at Lookfantastic

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — €15.90 at Amazon

## Where to buy

- Amazon.it: €115.99 (https://www.amazon.it/dp/B0862RV8F5?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €150.00 (https://www.notino.it/perricone-md/cold-plasma-plus-neck-chest-crema-rassodante-per-collo-e-decollete/p-16069906/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dimethicone, Cyclopentasiloxane, Glycerin, Niacinamide, Ethylhexyl Methoxycrylene, Pentylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Tetrahexyldecyl Ascorbate, Thioctic Acid, Acetyl Tetrapeptide-9, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Bisabolol, Xanthan Gum, Hydrogenated Phosphatidylcholine, Mannitol, Benzyl Alcohol, Stearic Acid, Isohexadecane, Polysilicone-11, Polysorbate 60, Sorbitan Isostearate, Caprylic Capric Triglyceride, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Aluminum Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin