# PCA SKIN Rejuvenating Serum for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [PCA SKIN](https://lovi.care/skincare/it/brands/pca-skin)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for dry skin as glycerin and squalane provide humectant and emollient benefits, though it lacks sufficient occlusive ingredients for optimal hydration of your dry or flaky skin.
- Gluconolactone and niacinamide offer mild exfoliation and improve skin tone, but the presence of Sd Alcohol 40-B may counteract the hydrating effects needed for your dry and sensitive skin.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Bisabolol and Aloe Barbadensis Leaf Juice.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glutathione, Squalane, Epigallocatechin Gallate, Aloe Barbadensis Leaf Juice

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction. ([Journal of Clinical and Diagnostic Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28384900/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## Why other serums fit dry sensitive skin better

- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

This product is highly praised for improving skin texture, reducing fine lines, and providing a radiant glow. Users frequently mention its lightweight, fast-absorbing formula. Some users with sensitive skin find the alcohol-heavy base to be drying or irritating.

- Liked: Improves radiance (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Refreshing experience (sometimes noted)
- Disliked: Drying formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritating ingredients (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does PCA SKIN Rejuvenating Serum work for dry sensitive skin?

This serum works moderately well for dry sensitive skin because glycerin and squalane help keep it soft, though it lacks enough sealing ingredients to fully comfort dry or flaky areas and contains alcohol that may dry it out further. Soother ingredients like bisabolol and aloe help keep it calm and safe from irritation. To work best for this skin, a treatment of this type needs rich moisturizing ingredients that lock in deep hydration and support the skin barrier without any drying alcohol.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin, squalane, bisabolol, and aloe leaf juice make this serum a fit for dry and sensitive skin by providing gentle moisture and a calm, soothing feel without irritation. However, a product for this skin needs richer sealing ingredients and a drying alcohol-free formula to lock in lasting hydration and protect the skin barrier.

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### What does Glutathione do for dry sensitive skin?

Glutathione helps improve moisture content and smoothness while reducing oxidative stress, making it a helpful option for dry sensitive skin. This ingredient may enhance hydration and elasticity while maintaining a gentle profile. To properly care for dry sensitive skin, a product of this type needs soothing and hydrating ingredients that support the skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in your evening routine after your toner and before your moisturizer. A product of this type needs rich, locking-in ingredients and alcohol-free hydrating agents to properly comfort dry skin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, but this serum needs richer oils and sealing ingredients to properly lock in moisture for your dry and sensitive skin.

### How often should I use this serum?

You can use this serum in the evening. It is unlikely to irritate your dry and sensitive skin, but a product of this type needs richer sealing ingredients and no drying alcohol to truly keep your skin soft and smooth.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry and sensitive skin, as it features soothing ingredients like bisabolol and aloe barbadensis leaf juice that help keep skin calm without heavy oils.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (sd alcohol 40-b).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €129.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — €57.00 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €380.10 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €20.40 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Sd Alcohol 40-B, Glycerin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Polysorbate 20, Bisabolol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isomalt, Sodium Pca, Sodium Lactate, Sodium Benzoate, Caprylyl Glycol, 1,2-Hexanediol, Peppermint Oil, Tocopherol, Squalane, Glutathione, Grapefruit Peel Oil, Citrus Aurantium Dulcis Peel Oil, Phytosterols, Tropolone, Epigallocatechin Gallate, Camellia Oleifera Leaf Extract, Aminomethyl Propanol, Tocotrienols, Squalene, Rice Bran Wax, Aloe Barbadensis Leaf Juice, Urea, Niacinamide, Glycine, Fructose, Vitis Vinifera Fruit Cell Extract Grape Fruit Cell Extract, Lecithin, Inositol, Rh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin