# PCA SKIN Rejuvenating Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [PCA SKIN](https://lovi.care/skincare/it/brands/pca-skin)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate skin rejuvenation for your combination skin, as gluconolactone and niacinamide gently exfoliate and improve skin tone, while Bisabolol and Aloe Barbadensis Leaf Juice provide supportive hydration and soothing effects. The formula lacks sufficient ingredients to directly address your acne, blemishes, and breakouts, and may not offer optimal oil control for your oilier areas.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients for your combination skin.
- The presence of Glycerin and Sodium PCA offers humectant action, providing moderate suitability for combination skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glutathione, Squalane, Epigallocatechin Gallate, Aloe Barbadensis Leaf Juice

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction. ([Journal of Clinical and Diagnostic Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28384900/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))

## What reviewers say

This product is highly praised for improving skin texture, reducing fine lines, and providing a radiant glow. Users frequently mention its lightweight, fast-absorbing formula. Some users with sensitive skin find the alcohol-heavy base to be drying or irritating.

- Liked: Improves radiance (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Refreshing experience (sometimes noted)
- Disliked: Drying formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritating ingredients (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does PCA SKIN Rejuvenating Serum work for acne-prone skin?

PCA SKIN Rejuvenating Serum works moderately well for acne-prone skin, as it gently exfoliates and calms the skin while providing light hydration. However, it lacks enough ingredients to directly target breakouts and may not control oil well enough in oily areas. An acne-prone product needs effective ingredients like niacinamide and propolis or zinc to help clear blemishes and balance oil.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because niacinamide and gluconolactone gently exfoliate and improve skin tone while aloe and bisabolol soothe and hydrate. However, acne-prone skin needs products with ingredients like propolis or zinc PCA to directly target blemishes and control oil.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Glutathione do for acne-prone skin?

Glutathione helps protect acne-prone skin against everyday environmental stress and oxidation. This ingredient is unlikely to clear breakouts on its own, so acne-prone skin needs a product that also targets pores, calms redness, and balances oil with ingredients like salicylic acid or niacinamide.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, making it simple and safe for sun exposure. Acne-prone skin needs a product of this type to include ingredients that directly target blemishes and breakouts while providing oil control.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, applying this treatment first and following with your retinol once your skin is used to it. The formula is unlikely to cause irritation for your acne-prone skin, though acne-prone skin needs products with targeted blemish-clearing ingredients and oil-balancing agents.

### How often should I use it?

You can use this treatment in the evening as part of your routine. Products of this type for acne-prone skin need ingredients that directly address breakouts and provide optimal oil control.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum works for acne-prone skin, though other products fit it better, because it lacks sufficient ingredients to directly address blemishes and may not offer optimal oil control for your oilier areas. Acne-prone skin needs ingredients that help control oil and clear pores, such as salicylic acid, retinoids, or targeted blemish-fighting extracts.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (sd alcohol 40-b).

## Alternatives for acne-prone skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €37.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Sd Alcohol 40-B, Glycerin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Polysorbate 20, Bisabolol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isomalt, Sodium Pca, Sodium Lactate, Sodium Benzoate, Caprylyl Glycol, 1,2-Hexanediol, Peppermint Oil, Tocopherol, Squalane, Glutathione, Grapefruit Peel Oil, Citrus Aurantium Dulcis Peel Oil, Phytosterols, Tropolone, Epigallocatechin Gallate, Camellia Oleifera Leaf Extract, Aminomethyl Propanol, Tocotrienols, Squalene, Rice Bran Wax, Aloe Barbadensis Leaf Juice, Urea, Niacinamide, Glycine, Fructose, Vitis Vinifera Fruit Cell Extract Grape Fruit Cell Extract, Lecithin, Inositol, Rh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/pca-skin/rejuvenating-serum/for/acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/pca-skin/rejuvenating-serum/for/acne-prone-skin