# Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Paula's Choice](https://lovi.care/skincare/it/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin and oily shine concerns is provided by retinaldehyde and retinol, which promote skin renewal and regulate sebum production. Niacinamide further aids in seboregulation, enhancing the treatment of oily shine.
- The formula also includes beneficial ingredients like squalane and hyaluronic acid to support hydration and skin barrier function, ensuring a balanced approach to skin renewal.
- This product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinaldehyde, Retinol, Niacinamide, Hyaluronic Acid, Squalane

## What the research says

- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with acne-prone and aging skin report significant improvements in skin clarity and texture, often describing the product as a "game changer" for stubborn breakouts and fine lines. While the dual-retinoid formula is praised for being surprisingly gentle and effective where other retinols failed, some users experienced an initial purging phase and noted the bright yellow formula can stain fabrics.

- Liked: Clears acne (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Smoothes texture (often mentioned)
- Liked: Pleasant texture (sometimes noted)
- Disliked: Initial purging phase (sometimes noted)
- Disliked: Stains fabric yellow (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Slow to show results (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment a great fit for combination skin?

This treatment is a great fit for your combination skin because retinaldehyde and retinol promote skin renewal and help control oily shine, while niacinamide further balances oil production. Squalane and hyaluronic acid also support hydration and protect your skin barrier so renewal stays balanced. This product is very safe for your skin, with no risk of irritation from harsh ingredients.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Which ingredients make this treatment a good fit for combination skin?

This treatment is a great fit for your combination skin because retinaldehyde, retinol, and niacinamide help renew skin and control oily shine. Squalane and hyaluronic acid further support hydration and keep your skin barrier balanced, while the formula is unlikely to cause irritation.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### What does Retinal do for combination skin?

Retinal helps smooth the skin and reduces signs of aging or breakouts when used regularly. It is unlikely to cause severe irritation when introduced gradually, keeping combination skin feeling calm and smooth.
Sources: [European Review for Medical and Pharmacological Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25219827/), [Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/21649816/)

### What does Retinol do for combination skin?

Retinol helps smooth fine lines, even out skin tone, and improve firmness in combination skin. It works by encouraging faster skin renewal and boosting collagen, though it may occasionally cause mild dryness or scaling while your skin adjusts.
Sources: [Archives of Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17515510/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, applied after cleansing and before moisturizing. Putting it in the evening keeps things simple and helps avoid extra sun sensitivity.

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in your morning routine and this treatment at night, as this keeps your skin calm and avoids overloading it.

### How often should I use this treatment?

Use this treatment in your evening routine, starting once a week and slowly increasing frequency as your skin adjusts. This gradual approach helps your skin renew itself smoothly while avoiding any potential irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment may cause an initial purging phase as your skin renews, but it is unlikely to cause routine breakouts since it balances oil production and supports a healthy skin barrier. Reviewers note this temporary adjustment period, which is a normal part of how the active ingredients work.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €75.00 (https://www.amazon.it/dp/B0DCVTQ4XV?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Cetearyl Alcohol, Retinaldehyde, Retinol, Caprylic Capric Triglyceride, Squalane, Butyrospermum Parkii Butter Shea Butter, Niacinamide, Tocopherol Vitamin E, Panthenol, Hyaluronic Acid, Allantoin, Bisabolol, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Aloe Barbadensis Leaf Juice, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin