# Origins Plantscription Multi-Powered Youth Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Origins](https://lovi.care/skincare/it/brands/origins)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate skin treatment for your normal skin with sensitivity, as acetyl hexapeptide-8 and palmitoyl tripeptide-1 help minimize fine lines and wrinkles while niacinamide and algae extract provide soothing benefits for redness.
- The formula includes glycerin and rosemary leaf extract for hydration and barrier repair, offering general skincare benefits suitable for your concerns.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Sodium Hyaluronate, Acetyl Hexapeptide-8, Anogeissus Leiocarpus Bark Extract, Hibiscus Abelmoschus Extract

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- An alcohol-based hand rub containing farnesol and benzethonium chloride achieved a 3.22 log10 microbial reduction after the first application and 5.49 log10 after the tenth in human volunteers without causing skin irritation. ([International Journal of Hygiene and Environmental Health, 2006](https://pubmed.ncbi.nlm.nih.gov/16750419/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A Hibiscus Abelmoschus seed extract mimicked heparan sulphate-like properties to protect FGF-2 from thermal degradation and stimulated sulphated GAG synthesis in skin fibroblasts. ([International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19849726/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its lightweight, fast-absorbing texture that effectively hydrates and plumps the skin, often noting an immediate 'youthful bounce' and smoother texture. While many long-time users appreciate its ability to reduce redness and fine lines, a significant portion of recent reviews express disappointment over a formula change, citing a watery consistency and inferior packaging compared to the original version.

- Liked: Lightweight absorption (mostly mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Inferior new formula (often mentioned)
- Liked: Firming effects (sometimes noted)
- Liked: Soothing and calming (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Poor packaging quality (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Origins Plantscription Multi-Powered Youth Serum work for sensitive skin?

This treatment works moderately well for sensitive skin, offering soothing benefits for redness along with ingredients that help minimize fine lines and wrinkles. A treatment of this type needs calming ingredients and antioxidants to target redness and irritation while maintaining a safe profile for sensitive skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum works for sensitive skin because niacinamide and algae extract help calm redness, while glycerin and sodium hyaluronate provide hydration. To fit this skin type best, a product of this type needs soothing components and effective ingredients that target redness and irritation without any risk of irritation.

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in the evening routine, after cleansing and toning and before moisturizing, for simplicity and extra safety around sun exposure. This skin type needs a product that includes soothing ingredients and hydrators to calm redness and repair the barrier while addressing fine lines.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol, but apply retinol first, wait a few minutes for it to sink in, and then follow with this serum. This product works for sensitive skin, though it needs calming plant extracts and gentle hydrators to keep delicate skin feeling smooth and comfortable without irritation.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine for sensitive skin. To fit this sensitive skin better, a product of this type needs soothing ingredients and gentle hydrators that calm redness and repair the skin barrier without causing irritation.

### Can it clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as its safety profile shows no harsh ingredients that typically trigger irritation. To care for sensitive skin, this type of product needs soothing components like niacinamide and algae extract along with gentle hydrating ingredients.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, geraniol, citronellol, and limonene).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

- Amazon.it: €79.00 (https://www.amazon.it/dp/B0927BFCRK?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €71.50 (https://www.notino.it/origins/plantscription-multi-powered-youth-serum-siero-ringiovanente-viso/p-16164440/)
Prices checked 16 Oct – 1 Nov 2026.

## Ingredients

Water, Butylene Glycol, Niacinamide, Glycerin, Heptyl Undecylenate, Octyldodecanol, Glycereth-26, Sodium Acrylates Copolymer, Algae Extract, Illicium Verum Seed Oil Fruit Anise Seed Oil Fruit, Bergamot Oil Fruit, Pelargonium Graveolens Oil Flower, Lavandula Angustifolia Oil Lavender Oil, Lemon Peel Oil, Litsea Cubeba Oil Fruit, Citrus Nobilis Peel Oil Mandarin Orange Peel Oil, Nutmeg Kernel Oil, Citrus Aurantium Dulcis Oil, Rosa Damascena Oil Flower, Hibiscus Abelmoschus Extract, Carthamus Tinctorius Seed Oil, Linalool, Geraniol, Citronellol, Limonene, Anogeissus Leiocarpus Bark Extract, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Acetyl Octapeptide-3, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Hyaluronate, Sigesbeckia Orientalis Extract, Commiphora Mukul Extract Resin, Laminaria Digitata Extract, Glucosamine Hcl, Bambusa Vulgaris Extract, Caffeine, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Molasses Saccharum Officinarum Extrait De Mélasse Extract, Tocopheryl Acetate, Scutellaria Baicalensis Root Extract, Pyrus Malus Fruit Extract, Cucumis Sativus Fruit Extract, Pisum Sativum Extract, Caprylic Capric Triglyceride, Lecithin, Xanthan Gum, Caprylyl Glycol, Hexylene Glycol, Peg-8, Glyceryl Polymethacrylate, Carbomer, Polysorbate 20, Sodium Metabisulfite, Sodium Sulfite, Disodium Edta, Sodium Phytate, Bht, Potassium Sorbate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/origins/plantscription-multi-powered-youth-serum/for/sensitive-skin