# Olay Regenerist Regenerating Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Olay](https://lovi.care/skincare/it/brands/olay)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for redness and irritation due to the presence of niacinamide and allantoin, which provide soothing and anti-inflammatory effects, making it suitable for your normal, sensitive skin.
- Niacinamide and panthenol also offer humectant action and barrier repair, further supporting your normal skin type.
- The product is safe for your sensitive skin as it lacks prohibited or harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Palmitoyl Pentapeptide-4, Glycerin, Tocopheryl Acetate, Allantoin

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Based on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, making it ideal for layering. Many report softer, hydrated skin and a reduction in fine lines, contributing to a smoother appearance. A small number of users experienced breakouts or found the texture sticky.

- Liked: Effective hydration (mostly mentioned)
- Liked: Silky texture (mostly mentioned)
- Liked: Convenient packaging (sometimes noted)
- Liked: Fragrance-free option (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Ingredient concerns (rarely noted)
- Disliked: Packaging flaws (rarely noted)
- Disliked: Skin reactions (rarely noted)
- Disliked: Texture issues (rarely noted)
- Disliked: Value for money (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Olay Regenerist Regenerating Serum work for sensitive skin?

Olay Regenerist Regenerating Serum works moderately well for sensitive skin, helping soothe redness and irritation with niacinamide and allantoin while safely avoiding harsh ingredients. A treatment of this type needs a combination of potent antioxidants, soothing ingredients like panthenol, and hydrating components to provide optimal benefits and barrier support for sensitive skin without any risks of unsuitability.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide, allantoin, and panthenol make this serum a good fit because they help calm redness and soothe irritation while supporting the skin barrier. To suit sensitive skin best, a treatment of this type needs strong soothing ingredients, gentle hydrators, and a formula free from harsh irritants.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Palmitoyl Pentapeptide-4 do for sensitive skin?

Palmitoyl pentapeptide-4 is generally suitable for sensitive skin and helps smooth fine lines while supporting overall skin firmness. Because sensitive skin can easily react to active ingredients, a product of this type needs soothing components and a gentle formula to calm irritation while delivering anti-aging benefits.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Acta Biomaterialia, 2025](https://pubmed.ncbi.nlm.nih.gov/39694719/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine, after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help calm the skin and support your moisture barrier, followed by your retinol. To work best for sensitive skin, this type of product needs soothing ingredients like niacinamide and allantoin along with a gentle, fragrance-free formula that avoids harsh irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### How often should I use this serum?

Use this serum in the evening. Sensitive skin needs treatments with soothing ingredients like niacinamide and allantoin, along with barrier-supporting agents like glycerin and panthenol, to keep the skin calm and comfortable.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it lacks heavy, pore-clogging oils and harsh ingredients that typically trigger irritation. To consistently keep breakouts away while calming sensitive areas, a product of this type needs lightweight hydrators like glycerin and soothing ingredients like niacinamide.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Dimethicone, Glycerin, Niacinamide, Dimethicone Crosspolymer, Polymethylsilsesquioxane, Panthenol, Polyethylene, Palmitoyl Pentapeptide-4, Sodium Peg-7 Olive Carboxylate Oil, Tocopheryl Acetate, Allantoin, Camellia Sinensis Leaf Extract, Dimethiconol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dmdm Hydantoin, Iodopropynyl Butylcarbamate, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, C13-14 Isoparaffin, Aminomethyl Propanol, Laureth-4, Laureth-7, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/olay/regenerist-regenerating-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/olay/regenerist-regenerating-serum/for/sensitive-skin