numbuzin 5 Glutathione Vitamin Concentrated Serum for mature skin
Glutathione
Niacinamide
3-O-Ethyl Ascorbic Acid
Tranexamic Acid
Alpha-ArbutinHigh
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin, this serum features niacinamide and panthenol to support your skin barrier and provide hydration, though it does not directly target your primary concerns of wrinkles and fine lines.
- The inclusion of tranexamic acid and glutathione offers effective brightening and evening of skin tone, complementing the general skincare benefits provided by glycerin and panthenol.
- The product is safe for your skin, as it contains no harsh or irritating ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.7Overall rating based on 2.0k+ reviewsBased on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.
Highlights
Fades dark spots Mostly Mentioned
- “Acne marks faded noticeably”
- “Helps with pigmentation issues”
- “Sunspots have faded”
- “Clear up hyperpigmentation”
- “Reduces appearance of spots”
Gentle on skin Often Mentioned
- “No irritation”
- “Great for sensitive skin”
- “Gentle yet effective”
- “No stinging”
- “Soothing ingredients”
Lightweight texture Often Mentioned
- “Absorbs instantly”
- “Non-sticky formula”
- “Lightweight milky texture”
- “Sinks in quickly”
- “Does not feel heavy”
Hydrating glow Sometimes Noted
- “Natural glass-skin glow”
- “Leaves skin soft”
- “Very hydrating”
- “Restores natural glow”
- “Dewy finish”
Caused breakouts Rarely Noted
- “Caused tiny bumps”
- “More acne on my skin”
- “Triggered whiteheads”
- “Broke me out”
- “Clogged my pores”
Packaging issues Rarely Noted
- “Dropper is messy”
- “Hard to get last drops”
- “Bottle leaks slightly”
Slow results Rarely Noted
- “Did nothing to brighten”
- “No big improvement”
- “Takes a long time”
- “Saw no difference”
- “Overhyped results”
Tacky finish Rarely Noted
- “Left a slightly tacky feeling”
- “Sticky residue”
- “Felt heavy initially”
- “Greasy after application”
Sources: lovi.care, oliveyoung.com, iherb.com, stylevana.com, yesstyle.com, reddit.com, and more
Questions and answers
What makes numbuzin 5 Glutathione Vitamin Concentrated Serum a great fit for mature skin?
This serum is a great fit because ingredients like glutathione and tranexamic acid help brighten and even out your skin tone. It also contains niacinamide and panthenol to support your skin barrier and keep it hydrated.
Clinical, Cosmetic and Investigational Dermatology, 2014The Journal of Dermatological Treatment, 2017
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it includes tranexamic acid and glutathione to help brighten and even out your skin tone. It also contains niacinamide and panthenol to support your skin barrier and keep it hydrated.
Clinical, Cosmetic and Investigational Dermatology, 2014The Journal of Dermatological Treatment, 2017
What does Glutathione do for mature skin?
Glutathione helps mature skin by improving moisture, smoothness, and elasticity while reducing wrinkles and age spots. It also protects skin cells from everyday oxidative stress and environmental damage with a very safe profile.
Clinical, Cosmetic and Investigational Dermatology, 2014Molecules, 2026
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and toning, and before moisturizing, for simplicity and extra safety around sun exposure. It is safe for your skin, as it contains no harsh or irritating ingredients.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying this treatment first and following with your retinol, or by using them on alternating nights to keep your skin calm and smooth. This product is unlikely to irritate your skin because it contains no harsh ingredients and features soothing components like panthenol.
How often should I use this serum?
This treatment serum fits well into your evening routine and is safe to use once a day. It is unlikely to irritate your skin, though it does not directly target wrinkles and fine lines.
Clinical, Cosmetic and Investigational Dermatology, 2014The Journal of Dermatological Treatment, 2017
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh or irritating ingredients.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.
American Journal of Surgery, 2005Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.
Journal of Cosmetic Science, 2020Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.
Heliyon, 2023Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.
Journal of Cosmetic Dermatology, 2025
Ingredients
Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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