# Nu Skin ageLOC Tru Face Essence Ultra for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Nu Skin](https://lovi.care/skincare/it/brands/nu-skin)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as squalane and carthamus tinctorius seed oil provide emollient action and barrier repair, while pistacia lentiscus gum and centella asiatica extract contribute to skin firming and plumping.
- The formula includes antioxidants like tocopherol and dunaliella salina extract for general skincare support, which can be beneficial for wrinkles and fine lines, though more specialized anti-aging ingredients are not present.
- The product is safe for your normal skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Retinyl Palmitate, Tetrahexyldecyl Ascorbate, Centella Asiatica Extract, Dunaliella Salina Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Safflower seed oil and its active compound acacetin inhibit UVB-induced MMP-1 expression and regulate JNK1/2 and c-jun phosphorylation in HaCaT cells and human dermal fibroblasts, indicating potential as anti-wrinkle agents. ([Journal of Microbiology and Biotechnology, 2020](https://pubmed.ncbi.nlm.nih.gov/32522955/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- A Dunaliella salina extract significantly reduced skin glycation scores, histamine sensitivity, wrinkle counts, and spots compared to placebo under intense solar exposure. ([Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/35200634/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Phytoene- and phytofluene-rich tomato and Dunaliella salina extracts show no significant cytotoxic, genotoxic, irritant, or sensitizing potential, supporting their safe human topical use. ([Journal of Toxicology, 2018](https://pubmed.ncbi.nlm.nih.gov/29849613/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Nu Skin Tru Face Essence Ultra work for mature skin?

Nu Skin ageLOC Tru Face Essence Ultra works moderately well for mature skin, as it helps smooth and firm with helpful plant extracts while keeping your skin calm. To truly thrive, mature skin needs stronger anti-aging ingredients, potent antioxidants, and deeply hydrating components that specifically target wrinkles and loss of elasticity.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/35200634/)

### Which ingredients make this serum a good fit for mature skin?

Squalane and safflower seed oil help keep mature skin soft and smooth while supporting the skin barrier, and centella asiatica extract assists with firming. This serum needs higher concentrations of specialized anti-aging ingredients and potent antioxidants to be a top fit for mature skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Microbiology and Biotechnology, 2020](https://pubmed.ncbi.nlm.nih.gov/32522955/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What does Retinyl Palmitate do for mature skin?

Retinyl palmitate helps smooth out fine lines and wrinkles on mature skin while improving overall firmness, texture, and dryness. It may also help protect against sun-induced aging by supporting skin structure and reducing collagen breakdown.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though mature skin also needs targeted anti-aging actives like peptides and stronger retinoids for best results.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying your retinol product first and following with this formula to help keep your skin comfortable. This product is unlikely to cause irritation because it lacks harsh ingredients, but mature skin also needs potent specialized anti-aging ingredients and advanced collagen boosters.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

Use this treatment in your evening routine, applying it after cleansing and before moisturizing. To get better results on mature skin, a product of this type needs more specialized anti-aging ingredients along with powerful firming peptides and strong retinoids.

### Can it clog pores, cause breakouts or purging for mature skin?

This product is unlikely to clog pores or cause breakouts for mature skin, as it has a safe profile with no harsh ingredients. However, it offers only an average fit for this skin type, which needs specialized anti-aging ingredients like potent retinoids and peptides, along with deeply nourishing oils to truly smooth and firm mature skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/35200634/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Squalane, Dimethiconol, Caprylic Capric Triglyceride, Olea Europaea Oil Fruit Olive Oil Fruit, Carthamus Tinctorius Seed Oil, Dunaliella Salina Extract, Jojoba Seed Extract, Camellia Sinensis Leaf Extract, Pistacia Lentiscus Gum, Echinacea Angustifolia Extract, Commiphora Mukul Extract Resin, Hydrogenated Polydecene, Dimethicone, Centella Asiatica Extract, Tetrahexyldecyl Ascorbate, Octyldodecyl Oleate, Rice Bran Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Helianthus Annuus Extract Sunflower Extract, Retinyl Palmitate, Tocopherol, Tocopheryl Acetate, Ubiquinone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- France: https://lovi.care/skincare/fr/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/nu-skin/ageloc-tru-face-essence-ultra/for/mature-skin