# Neutrogena Stubborn Marks PM Treatment for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Neutrogena](https://lovi.care/skincare/it/brands/neutrogena)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for normal skin, as retinol and ascorbic acid provide antioxidant support and aid in collagen synthesis, while sodium hyaluronate offers hydration. However, it lacks targeted ingredients to directly address your redness and irritation concerns.
- The formulation is generally safe for your sensitive skin, avoiding harsh ingredients that could cause irritation.
- The presence of retinol and sodium hyaluronate offers excellent treatment for minimizing fine lines and wrinkles, smoothing texture and plumping the skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinol Sa, Ascorbic Acid, Sodium Hyaluronate, Glycerin, Hydrolyzed Myrtus Communis Leaf Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical treatments including podophyllotoxin, sodium nitrite, myrtle leaf extract, phenol, salicylic acid with lactic acid, SB206, and VP-102 were more efficacious than control in patients with molluscum contagiosum, whereas cantharidin, potassium hydroxide, and imiquimod showed varying degrees of efficacy. ([Clinics in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34920817/))
- Topical Myrtle solution significantly reduced inflammatory lesions and acne severity index compared to 1% clindamycin solution in patients with mild to moderate acne vulgaris. ([Journal of Pharmacopuncture, 2020](https://pubmed.ncbi.nlm.nih.gov/33408898/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Users with acne-prone skin report that this treatment effectively fades post-inflammatory hyperpigmentation and dark spots, often showing visible results within a few weeks. While many praise its ability to smooth skin texture and even out tone, a significant number of users experience initial dryness, flaking, or stinging as their skin adjusts to the retinol formula.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Small quantity (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying and irritation (sometimes noted)
- Disliked: Ineffective on wrinkles (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Stubborn Marks PM Treatment work for sensitive skin?

Neutrogena Stubborn Marks PM Treatment is an average fit for sensitive skin, as it is generally safe and avoids harsh ingredients, but it lacks targeted ingredients for redness and irritation. A treatment of this type needs ingredients that directly soothe redness and irritation while remaining safe for sensitive skin.

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment is a moderate fit for your sensitive skin because retinol and ascorbic acid help smooth texture and provide antioxidant support while sodium hyaluronate hydrates. However, a treatment for sensitive skin also needs soothing ingredients to directly calm redness and irritation without causing stinging.

### What does Retinol SA do for sensitive skin?

Retinol SA is unlikely to be a good fit for sensitive skin because traditional forms of retinol frequently cause stinging and scaling. Sensitive skin needs gentle alternatives like bakuchiol, which helps smooth and brighten skin without the irritation.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Vitamin C do for sensitive skin?

Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine, placed after your toner and before your moisturizer. Putting treatments in the evening provides extra safety around sun exposure for sensitive skin.

### Can I use this treatment with benzoyl peroxide, and in what order?

It is generally safe to use this treatment along with benzoyl peroxide, but because both can dry or irritate sensitive skin, you should introduce them slowly and use a soothing moisturizer afterward. Applying benzoyl peroxide and a retinoid together requires careful monitoring since combining strong active ingredients may increase the likelihood of peeling and discomfort.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this treatment?

This treatment is used in the evening once a week to start, and people who tolerate it well and see good results may carefully use it more often. It is generally safe for sensitive skin, but a product of this type for your skin needs soothing and calming ingredients to address redness and irritation.

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

This treatment is unlikely to cause breakouts, but it may cause drying and irritation on sensitive skin since it contains retinol. A product for sensitive skin needs calming and soothing ingredients like centella asiatica or aloe vera to keep redness at bay while treating marks.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Glycerin, Ppg-15 Stearyl Ether, Stearyl Alcohol, Cetearyl Alcohol, Butylene Glycol, Ceteareth-20, Isohexadecane, Dimethicone Crosspolymer, Trisiloxane, Phenoxyethanol, Caprylyl Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylamide, C13-14 Isoparaffin, Chlorphenesin, Hydrolyzed Myrtus Communis Leaf Extract, Polysorbate 20, Bht, Retinol, Disodium Edta, Sodium Hyaluronate, Ascorbic Acid, Laureth-7, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin
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