# Neutrogena Stubborn Marks PM Treatment for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Neutrogena](https://lovi.care/skincare/it/brands/neutrogena)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers moderate exfoliation and hydration for your combination skin, as retinol helps regulate desquamation and sodium hyaluronate provides humectant action, though it lacks specialized ingredients to address oily shine.
- The formula is generally safe for your combination skin, with no harsh ingredients that would cause irritation.
- While it provides general skincare benefits like plumping and smoothing fine lines, its primary function is not aligned with your main goal of managing oily shine.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinol Sa, Ascorbic Acid, Sodium Hyaluronate, Glycerin, Hydrolyzed Myrtus Communis Leaf Extract

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical treatments including podophyllotoxin, sodium nitrite, myrtle leaf extract, phenol, salicylic acid with lactic acid, SB206, and VP-102 were more efficacious than control in patients with molluscum contagiosum, whereas cantharidin, potassium hydroxide, and imiquimod showed varying degrees of efficacy. ([Clinics in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34920817/))
- Topical Myrtle solution significantly reduced inflammatory lesions and acne severity index compared to 1% clindamycin solution in patients with mild to moderate acne vulgaris. ([Journal of Pharmacopuncture, 2020](https://pubmed.ncbi.nlm.nih.gov/33408898/))

## What reviewers say

Users with acne-prone skin report that this treatment effectively fades post-inflammatory hyperpigmentation and dark spots, often showing visible results within a few weeks. While many praise its ability to smooth skin texture and even out tone, a significant number of users experience initial dryness, flaking, or stinging as their skin adjusts to the retinol formula.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Small quantity (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying and irritation (sometimes noted)
- Disliked: Ineffective on wrinkles (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Stubborn Marks PM Treatment a great fit for combination skin?

Neutrogena Stubborn Marks PM Treatment is a great fit for your combination skin because it offers moderate exfoliation and hydration, as retinol helps regulate skin shedding and sodium hyaluronate keeps skin soft. The formula is also generally safe for your skin, with no harsh ingredients that would cause irritation.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this treatment a good fit for combination skin?

This treatment is a good fit for combination skin because retinol helps smooth and renew the skin while sodium hyaluronate adds much-needed moisture. It is generally safe for your skin type and unlikely to cause irritation.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Retinol SA do for combination skin?

Retinol SA helps smooth out fine lines and uneven tone while keeping combination skin balanced. It may improve firmness and texture over time, though an average fit for combination skin also needs soothing and hydrating ingredients to maintain a calm and comfortable feel.
Sources: [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607905/), [Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37615835/)

### What does Vitamin C do for combination skin?

Vitamin C helps brighten dull areas and smooth out uneven texture on combination skin while protecting against daily environmental stress. It may also help keep pores clear and skin firm by supporting collagen production, though drier spots may need an added moisturizer to stay comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this treatment with benzoyl peroxide, and in what order?

You can use this treatment alongside benzoyl peroxide, but apply them at different times or on alternate nights to avoid heavy irritation. Since both ingredients are quite active on the skin, separating them helps maintain a calm and smooth complexion.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this treatment?

This treatment fits into your evening routine. You can start using it once a week, and if your skin feels comfortable and looks good, you may gradually use it more often.

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to clog pores or cause breakouts on combination skin, and it is generally safe without harsh ingredients that cause irritation. However, because it contains retinol which speeds up skin renewal, you may experience some mild initial purging or peeling as your skin adjusts.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Glycerin, Ppg-15 Stearyl Ether, Stearyl Alcohol, Cetearyl Alcohol, Butylene Glycol, Ceteareth-20, Isohexadecane, Dimethicone Crosspolymer, Trisiloxane, Phenoxyethanol, Caprylyl Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylamide, C13-14 Isoparaffin, Chlorphenesin, Hydrolyzed Myrtus Communis Leaf Extract, Polysorbate 20, Bht, Retinol, Disodium Edta, Sodium Hyaluronate, Ascorbic Acid, Laureth-7, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin