# Neutrogena Hydro Boost Hyaluronic Acid Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Neutrogena](https://lovi.care/skincare/it/brands/neutrogena)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines by leveraging the hydrating power of sodium hyaluronate and glycerin to plump the skin and reduce the appearance of creases.
- The inclusion of calcium pantothenate further supports skin barrier function and hydration, complementing the primary humectants.
- The product is safe for your skin, containing no harsh ingredients and featuring soothing sodium hyaluronate to prevent irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Hydration Complex

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Calcium pantothenate aftercare accelerated wound closure and exerted its healing-promoting effects partly via MMP-3, as skin models with MMP-3 knockdown exhibited slower wound closure compared to controls. ([Lasers in Medical Science, 2022](https://pubmed.ncbi.nlm.nih.gov/33990899/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, non-greasy texture that deeply hydrates dry and sensitive skin, leaving it feeling plump and soft. While most find it an effective moisture booster that layers well under makeup, some users with very dry skin feel it requires an additional heavy moisturizer to seal in the benefits.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Fast absorption (often mentioned)
- Liked: Fragrance-free option (sometimes noted)
- Liked: Softens skin (sometimes noted)
- Disliked: Packaging design issues (sometimes noted)
- Disliked: Insufficient hydration (rarely noted)
- Disliked: Small quantity (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Neutrogena Hydro Boost Serum a great fit for mature skin?

This serum is a great fit because it uses sodium hyaluronate and glycerin to plump the skin and smooth out fine lines and wrinkles. It also includes calcium pantothenate to support your skin barrier and keep it soft and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit because sodium hyaluronate and glycerin plump the skin to smooth out wrinkles and fine lines. Calcium pantothenate also helps support the skin barrier and keep moisture locked in.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Hydration Complex do for mature skin?

Hydration Complex helps mature skin stay hydrated, smooth, and elastic while softening the look of wrinkles. It supports skin barrier function to keep dry skin comfortable and healthy.
Sources: [Dermatology and Therapy, 2025](https://pubmed.ncbi.nlm.nih.gov/41071523/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, keeping things simple and safe around sun exposure. Using sodium hyaluronate and glycerin helps plump the skin and smooth out fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol or as a buffer to help keep mature skin soft and calm. Using a hydrating serum alongside retinol is unlikely to cause irritation and may help reduce dryness while supporting your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How often should I use this serum?

This serum is a great fit for your mature skin and is generally used in the evening as part of your routine. Using it daily helps plump the skin and smooth out fine lines and wrinkles by drawing in moisture.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it features a lightweight, soothing formula without heavy oils. It helps keep the skin calm and hydrated while supporting the skin barrier to prevent irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this hydrating serum around the eyes and on your body to help smooth out fine lines and keep the skin plump. Because the skin around the eyes is very thin, gentle ingredients like sodium hyaluronate and glycerin are unlikely to cause irritation while boosting moisture.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €14.90 (https://www.amazon.it/dp/B0CXRFVLTH?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Glycerin, Dimethicone, Sodium Hyaluronate, Phenoxyethanol, Calcium Pantothenate, Sodium Hydroxide, Ethylhexylglycerin, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/hydro-boost-hyaluronic-acid-serum/for/mature-skin