# Neora Advanced SIG-1273 Concentrated Serum for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Neora](https://lovi.care/skincare/it/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate hydration for your dry and flaky skin, as glycerin and sodium hyaluronate provide humectant action to attract moisture.
- While the formula is generally safe and free from harsh ingredients for your dry and sensitive skin, it lacks sufficient emollient ingredients for optimal hydration.
- The product is safe for your skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit dry sensitive skin better

- Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35274433/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application. ([Colloids and Surfaces. B, Biointerfaces, 2019](https://pubmed.ncbi.nlm.nih.gov/30974262/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neora SIG-1273 Concentrated Serum work for dry sensitive skin?

This serum offers moderate hydration for your dry and flaky skin, but it lacks sufficient softening ingredients for optimal moisture. A product for this skin needs rich hydrating and nourishing components, ceramides, and skin barrier support.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Sodium hyaluronate and glycerin make this serum a fit by attracting moisture to help soothe dry and flaky skin. A treatment of this type needs richer softening ingredients and ceramides to fully comfort dry sensitive skin and lock in lasting moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### What does Glycerin do for dry sensitive skin?

Glycerin helps dry sensitive skin by drawing moisture into the skin and keeping it there, making the skin soft and smooth. It is very gentle and unlikely to cause irritation while improving how well the skin holds onto water. This type of skin needs ingredients that boost hydration and repair the barrier without causing stinging.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine before your moisturizer for simplicity and extra safety around sun exposure. Because your skin is dry, this type of product also needs rich softening ingredients to lock in moisture and keep it smooth.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment after your soothing toner and before your moisturizer in your evening routine. This helps keep your dry and sensitive skin calm and hydrated, though this type of product also needs rich, nourishing ingredients and softening oils to fully care for flaky skin.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. A product of this type needs rich smoothing oils and butters to give dry and sensitive skin the deeper moisture it needs.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free from heavy oils and harsh ingredients that typically trigger blemishes. It provides moderate moisture, though this skin type generally needs richer, softening ingredients to truly stay smooth and comfortable.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €129.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — €57.00 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €380.10 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €20.40 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin