NATURIUM Multi-Peptide Advanced Serum for mature skin
Multi-Peptide Blend
Ferulic Acid
Hydrolyzed Collagen
Squalane
Acetyl Hexapeptide-8
High
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum is highly suitable for your normal skin, as Acetyl Hexapeptide-8 and Copper Palmitoyl Heptapeptide-14 effectively target wrinkles and fine lines by stimulating collagen production. Ferulic Acid and sunflower extract further enhance antioxidant protection and skin hydration, complementing your skin's natural balance.
- The inclusion of ingredients like hydrolyzed collagen and lactic acid/glycolic acid copolymer supports skin elasticity and texture refinement, addressing your primary concerns.
- The product has a strong safety profile, with soothing sunflower and rosemary leaf extracts and the absence of harsh ingredients, making it gentle for your normal skin.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.4Overall rating based on 400+ reviewsUsers with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.
Highlights
Elegant texture Often Mentioned
- “silky application”
- “absorbs quickly”
- “layers well”
- “non-sticky finish”
Hydrating and plumping Often Mentioned
- “deeply moisturizing”
- “skin feels bouncy”
- “lightweight hydration”
- “non-greasy feel”
Improves skin texture Often Mentioned
- “smoother complexion”
- “softer skin”
- “reduces roughness”
- “glass-like finish”
Great value Sometimes Noted
- “affordable price”
- “high-quality ingredients”
- “beats expensive brands”
- “good size”
Visible anti-aging Sometimes Noted
- “fine lines softened”
- “firmer appearance”
- “youthful glow”
- “less tired-looking”
Poor pump design Sometimes Noted
- “pump stops working”
- “hard to dispense”
- “product left at bottom”
- “cap breaks easily”
Caused breakouts Rarely Noted
- “cystic acne”
- “small bumps”
- “clogged pores”
- “skin reaction”
Runs out quickly Rarely Noted
- “bottle empties fast”
- “small quantity”
- “opaque bottle hides level”
- “used up in weeks”
Skin irritation Rarely Noted
- “stinging sensation”
- “burning upon application”
- “redness”
- “sensitivity flare-up”
Sources: lovi.care, naturium.com, space nk.com, target.com, ulta.com, reddit.com, and more
Questions and answers
What makes Naturium Multi-Peptide Advanced Serum a great fit for mature skin?
This serum is a great fit for mature skin because its multi-peptide blend, acetyl hexapeptide-8, and hydrolyzed collagen help smooth out wrinkles and improve firmness. Ferulic acid adds antioxidant protection, while soothing extracts keep this formula gentle and safe for daily use.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Which ingredients make this serum a good fit for mature skin?
Naturium Multi-Peptide Advanced Serum is a great fit for mature skin because it contains acetyl hexapeptide-8 and copper palmitoyl heptapeptide-14, which target wrinkles by stimulating collagen production. Ferulic acid and hydrolyzed collagen further enhance antioxidant protection and elasticity, helping keep mature skin smooth and firm.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
What do Peptides do for mature skin?
Peptides help smooth fine lines and make mature skin feel firmer and more elastic by encouraging collagen production. They also improve skin hydration and help repair signs of aging.
Journal of Cosmetic Dermatology, 2023International Journal of Cosmetic Science, 2009
What does Ferulic Acid do for mature skin?
Ferulic acid helps protect mature skin from sun damage and pollution while improving hydration, firmness, and signs of photoaging. It also helps boost the performance of other antioxidants like vitamins C and E to keep skin looking smooth and even.
Journal of the American Academy of Dermatology, 2008Dermatologic Therapy, 2022
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and toning, followed by your moisturizer. Applying treatments in the evening helps keep things simple and avoids extra safety concerns around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol, applying the serum first and letting it absorb before you put on your retinol. This pairing helps smooth the skin while keeping the routine gentle since the serum features soothing extracts.
How often should I use this serum?
This treatment serum fits well into your evening routine, where you can use it every day or start a few nights a week to see how your skin responds. Using antioxidant-rich serums as part of a daily skincare routine helps smooth fine lines and maintain a healthy, youthful look over time.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts for mature skin since very few reviewers mention them and the formula avoids harsh ingredients. It also includes soothing sunflower and rosemary leaf extracts, helping to keep your skin calm.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Cod skin collagen peptide/chitosan-based temperature-sensitive gel (CS/CSCPs/β-GP gel) synergistically enhanced the anti-photoaging effect of CSCPs in an ultraviolet-irradiated mouse model by inhibiting ROS, suppressing inflammatory factors, and preventing collagen degradation.
Drug Design, Development and Therapy, 2023A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects.
Dermatology and Therapy, 2026Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening.
Dermatologic Therapy, 2022Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo.
The Journal of Dermatological Treatment, 2025Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control.
Journal of Cosmetic Dermatology, 2008Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026
Ingredients
Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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