# Natura Bissé C+C Vitamin Complex for oily acne-prone skin

**Lovi Fit: Low fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Natura Bissé](https://lovi.care/skincare/it/brands/natura-bisse)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for oily acne-prone skin; the serums alongside fit it better.

## Why this fit

- Offers moderate skin brightening for your oily skin due to Sodium Ascorbyl Phosphate, which helps even skin tone, but it lacks sufficient ingredients for optimal oil control.
- While it provides general hydration and soothing benefits, these are largely supportive and not directly targeted at your primary concerns of acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin): Low (this page)

## Key ingredients

Ascorbic Acid, Vitamin E, Rosa Canina Oil Fruit, Hydrolyzed Collagen, Tocopherol

## What the research says

- The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate. ([Experimental Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22142309/))
- Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days. ([Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/))
- Topical application of tocopherol succinate ethosomal gel decreased erythema, melanin, and sebum levels while improving moisture content and skin elasticity in 34 human women. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38268219/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37605366/))
- Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986857/))
- A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36839792/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.

- Liked: Brightens dull skin (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Potential irritation (sometimes noted)
- Liked: Firming effect (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Natura Bissé C+C Vitamin Complex a weak match for oily acne-prone skin?

This treatment is a weak match because it lacks enough ingredients for oil control and does not target acne and breakouts directly. Oily acne-prone skin needs products with ingredients like niacinamide and propolis that manage excess oil and address blemishes without causing irritation.
Sources: [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Which ingredients make this serum a poor fit for oily acne-prone skin?

This treatment is a weak match for your skin because it lacks enough ingredients for oil control and targeting breakouts, even though it contains helpful brightening agents like Sodium Ascorbyl Phosphate. A product of this type needs effective ingredients like niacinamide and propolis that manage excess oil and smooth texture without causing irritation or breakouts.
Sources: [Experimental Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22142309/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### What does Vitamin C do for oily acne-prone skin?

Vitamin C helps brighten skin, smooth out texture, and improve uneven spots for oily acne-prone skin. It may also help fade marks left behind by blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Vitamin E do for oily acne-prone skin?

Vitamin E helps reduce oiliness, redness, and dark spots on oily acne-prone skin while improving moisture. It also helps calm irritation and smooth the skin when used consistently.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38268219/), [Giornale Italiano Di Dermatologia E Venereologia, 2014](https://pubmed.ncbi.nlm.nih.gov/25068233/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though it is a weak match for your oily acne-prone skin. A product of this type needs dedicated oil-controlling and breakout-targeting ingredients to properly suit this skin type.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first and letting it absorb before adding this vitamin complex. Because this is a weak match for oily acne-prone skin, an acne-focused product of this type needs stronger oil control ingredients and targeted blemish-fighting actives.

### How often should I use this serum?

You can use this serum in the evening as part of your routine for oily acne-prone skin. Because it is a weak match for your skin, an oily acne-prone skin type needs a product of this type that features targeted oil-controlling and breakout-clearing ingredients.

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment may not be the best match because it lacks sufficient ingredients for optimal oil control and does not target acne or blemishes. Oily acne-prone skin needs a product of this type that features targeted oil-balancing ingredients and lightweight hydrators to help keep pores clear.
Sources: [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.10 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €34.95 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €24.75 at Amazon

## Routine for oily acne-prone skin

### AM

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — €40.49 at Amazon

### PM

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/it/p/pyunkang-yul/deep-cleansing-oil/for/oily-acne-prone-skin) — Superior fit — €25.00 at Amazon
- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Cleansing Toner: [COSRX AHA/BHA Clarifying Treatment Toner](https://lovi.care/skincare/it/p/cosrx/aha-bha-clarifying-treatment-toner/for/oily-acne-prone-skin) — Superior fit — €13.89 at Amazon
- Serum or Treatment: [L'Oréal Paris Revitalift Derm Intensives Vitamin C Serum](https://lovi.care/skincare/it/p/l-oreal-paris/revitalift-12-vitamin-c-e-salicylic-serum/for/oily-acne-prone-skin) — Superior fit — €14.21 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon

### Weekly

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/it/p/pyunkang-yul/deep-cleansing-oil/for/oily-acne-prone-skin) — Superior fit — €25.00 at Amazon
- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/oily-acne-prone-skin) — Superior fit — €49.00 at Amazon
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/oily-acne-prone-skin) — High fit — €19.79 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Serum or Treatment: [L'Oréal Paris Revitalift Derm Intensives Vitamin C Serum](https://lovi.care/skincare/it/p/l-oreal-paris/revitalift-12-vitamin-c-e-salicylic-serum/for/oily-acne-prone-skin) — Superior fit — €14.21 at Amazon

## Where to buy

- Amazon.it: €129.20 (https://www.amazon.it/dp/B0B7B9KDCZ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin