# MISSHA Time Revolution Night Repair Ampoule for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [MISSHA](https://lovi.care/skincare/it/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Suitable for normal skin, this ampoule leverages Bifida Lysate Ferment and Niacinamide to strengthen the skin barrier and improve skin tone, offering general hydration with Glycerin and Sodium Hyaluronate.
- While it provides excellent barrier repair and tone evening, it lacks specialized ingredients like Retinol or peptides to effectively target wrinkles and fine lines.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Chamomilla Recutita Flower Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Retinol, Copper Tripeptide-1, Ubiquinone

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, this anti-aging overnight treatment is highly regarded for its ability to deeply hydrate, plump, and brighten the skin, significantly improving texture and reducing fine lines, particularly for those with dry, mature, or dull complexions. While generally well-tolerated, a moderate number of users with sensitive or acne-prone skin reported experiencing breakouts or irritation, and a small number noted a sticky or oily feel and a noticeable herbal scent.

- Liked: Deeply hydrates skin (mostly mentioned)
- Liked: Brightens and adds glow (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Affordable luxury dupe (sometimes noted)
- Disliked: May cause breakouts (sometimes noted)
- Disliked: Feels sticky or oily (rarely noted)
- Disliked: Noticeable herbal scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MISSHA Time Revolution Night Repair work for mature skin?

This ampoule works well enough for mature skin by strengthening the skin barrier and evening tone, though other products fit it better. To truly match what mature skin needs, a treatment of this type requires specialized ingredients like high concentrations of retinol and peptides to effectively target wrinkles and fine lines, along with potent antioxidants and humectants to improve skin elasticity and moisture retention.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum fits mature skin reasonably well by using niacinamide and bifida lysate ferment to strengthen the skin barrier and even out tone, while glycerin and sodium hyaluronate provide general hydration. However, mature skin needs a product of this type to feature targeted anti-aging ingredients like potent peptides and higher levels of retinol to effectively smooth fine lines and improve elasticity.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for mature skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, which keeps mature skin feeling soft and comfortable. It also provides antioxidant support that may protect against everyday stress, though products for mature skin also need firming and smoothing ingredients like peptides and retinol.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in your evening routine after cleansing and before moisturizing. Mature skin needs products with powerful anti-aging ingredients like retinol and peptides to effectively target wrinkles and fine lines.

### Can I use this serum with AHA, and in what order?

You can use this treatment alongside an AHA by applying the AHA first after cleansing, waiting for it to absorb, and then following with this serum. This approach helps smooth the skin while keeping it comfortable, though mature skin generally needs targeted wrinkle-fighting ingredients like retinol and peptides.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. A product of this type for mature skin needs powerful anti-aging ingredients like retinols and peptides to effectively target wrinkles and fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This product may cause breakouts for some people, as moderate complaints are reported by reviewers. However, it is unlikely to cause harsh irritation since it contains soothing ingredients like chamomile extract.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Bifida Lysate Ferment, Glycereth-26, Juniperus Chinensis Xylem Extract, Sorbus Commixta Extract, Bis-Peg-18 Methyl Ether Dimethyl Silane, Butylene Glycol, Glycerin, Niacinamide, Betaine, Leuconostoc Radish Ferment Filtrate, Cyclopentasiloxane, Ethyl Hexanediol, Dimethicone, Grifola Frondosa Extract Ferment Filtrate Maitake Extract Ferment Filtrate Ophioglossum Vulgatum Extract Ferment Filtrate, Peg-11 Methyl Ether Dimethicone, Peg-40 Hydrogenated Castor Oil, Ppg-26-Buteth-26, Polysorbate 20, Carbomer, Glyceryl Caprylate, Triethanolamine, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Dimethicone Vinyl Dimethicone Crosspolymer, Hydrolyzed Rice Extract, Lactobacillus Rice Ferment Filtrate, Portulaca Oleracea Extract, Sea Water, Sodium Hyaluronate, Octyldodecanol, Carthamus Tinctorius Oleosomes, Acacia Arabica Bark Extract Stem, Hydrolyzed Extensin, Adenosine, Xanthan Gum, Aronia Arbutifolia Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Blueberry Fruit Extract, Dipropylene Glycol, Echium Plantagineum Seed Oil, Tocopheryl Acetate, Cyclomethicone, Hydrogenated Lecithin, Disodium Edta, Ascorbyl Tetraisopalmitate, Dextrin, Lactobacillus Ferment, Lactococcus Lysate Ferment, Laminaria Digitata Extract, Manilkara Multinervis Leaf Extract, Theobroma Cacao Seed Extract, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Saccharomyces Ferment Filtrate, Lactobacillus Soybean Extract Ferment, Glyceryl Polyacrylate, Saccharomyces Viscum Album Extract Ferment Mistletoe Extract Ferment, Yeast Extract Ferment, Pogostemon Cablin Oil, Dimethiconol, Cardiospermum Halicacabum Vine Extract Flower Leaf, Helianthus Annuus Seed Oil Sunflower Seed Oil, Pseudoalteromonas Extract Ferment, Alpha-Glucan Oligosaccharide, Limnanthes Alba Seed Oil, Hydrolyzed Wheat Protein, Beta-Sitosterol, Panthenol, Hydrolyzed Soy Protein, Propylene Glycol, Cholesterol, Ceteth-24, Choleth-24, Glyceryl Arachidonate, Glyceryl Linoleate, Glyceryl Linolenate, Ubiquinone, Hydroxypropyltrimonium Maltodextrin Crosspolymer, Cetyl Phosphate, Caprylic Capric Triglyceride, Macadamia Ternifolia Seed Oil, Retinol, Lecithin, Phenoxyethanol, Cucumis Melo Fruit Extract, Amaranthus Caudatus Seed Extract, Biotin, Brassica Campestris Sterols, Peg-5 Rapeseed Sterol, Sodium Ascorbyl Phosphate, Tripeptide-10 Citrulline, Acetyl Hexapeptide-8, Bht, Ceteth-3, Ceteth-5, Copper Tripeptide-1, Silica, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-ampoule/for/mature-skin