Medik8 Oxy-R Peptides for dry skin
Oxyresveratrol
Peptides
Sodium Hyaluronate
Lactic Acid
GlycerinHigh
- HighDry Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for dry skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your dry skin due to the humectant action of Glycerin and Sodium Hyaluronate, complemented by the gentle renewal from Gluconolactone and Lactic Acid, which also offer moderate exfoliation for dry or flaky skin.
- The product provides excellent skin brightening, effectively evening your skin tone with Hydroxyresveratrol and Tetrapeptide-30.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.4Overall rating based on 1.1k+ reviewsBased on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.
Highlights
Fades dark spots Often Mentioned
- “pigmentation lightened slightly”
- “fading uneven skin tone”
- “dark spots visibly reduced”
- “helped post-acne marks”
Improves skin texture Often Mentioned
- “skin feels firmer”
- “looks more awake”
- “smoother texture”
- “glass-like glow”
- “healthier overall”
Fast absorption Sometimes Noted
- “absorbs fast”
- “soaks into skin easily”
- “non-greasy”
- “layers well”
- “lightweight silky serum”
Gentle formulation Sometimes Noted
- “no irritation at all”
- “gentle to use”
- “suitable for sensitive skin”
- “didn't dry me out”
Rapid results Sometimes Noted
- “results in 7 days”
- “brighter and clearer quickly”
- “works fast”
- “noticeable difference in weeks”
Ineffective for some Sometimes Noted
- “no difference”
- “haven't noticed changes”
- “not impressed”
- “melasma didn't budge”
Caused breakouts Rarely Noted
- “caused breakouts”
- “mild reaction”
- “bumps appeared”
- “skin purging”
Packaging issues Rarely Noted
- “click mechanism tricky”
- “hard to activate”
- “dropper issues”
Short shelf life Rarely Noted
- “use within 6 weeks”
- “runs out quickly”
- “two small bottles”
- “oxidizes if not used fast”
Sources: lovi.care, medik8.com, spacenk.com, lookfantastic.com, cultbeauty.co.uk, dermstore.com, and more
Questions and answers
What makes Medik8 Oxy-R Peptides a great fit for dry skin?
Medik8 Oxy-R Peptides is a great fit for dry skin because glycerin and sodium hyaluronate draw in moisture, while gluconolactone and lactic acid gently renew flaky skin without irritation. It also helps brighten and even out your skin tone using hydroxyresveratrol and tetrapeptide-30.
Which ingredients make this serum a good fit for dry skin?
Glycerin and Sodium Hyaluronate make this serum a great fit for dry skin by pulling in moisture, while Gluconolactone and Lactic Acid gently smooth away flaky patches. These ingredients work together to keep dry skin feeling soft and comfortable without irritation.
What does Oxyresveratrol do for dry skin?
Oxyresveratrol helps hydrate dry skin and keeps it soft and smooth by locking in moisture. It may also calm irritation and brighten your complexion while improving overall skin texture.
What do Peptides do for dry skin?
Peptides help dry skin by supporting skin barrier health and improving moisture retention. Regular use may also enhance skin firmness and smooth out the texture of dry skin over time.
Where does this serum go in a skincare routine for dry skin?
This treatment serum goes in your evening routine after cleansing and before your moisturizer. Using it at night keeps things simple and avoids extra safety concerns around sun exposure.
Can I use it with retinol, and in what order?
You can use this treatment with retinol by applying the treatment in your evening routine and following it with a moisturizer. It is unlikely to cause irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How often should I use it?
Use this treatment in your evening routine, starting just once a week to see how your skin reacts. Because it contains gentle renewing ingredients, you may carefully use it more often if your dry skin tolerates it well and shows good results.
Can it clog pores, cause breakouts or purging for dry skin?
Medik8 Oxy-R Peptides is a great fit for dry skin and is unlikely to cause breakouts, as reviews report this issue only rarely and the formula contains soothing components without harsh ingredients. It helps keep skin soft and smooth while evening your skin tone.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women.
Journal of Cosmetic Dermatology, 2017Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect.
Food and Chemical Toxicology, 2011Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls.
AAPS PharmSciTech, 2012Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells.
Scientific Reports, 2024Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.
Cutis, 2004Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.
Journal of the American Academy of Dermatology, 1992A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.
The Journal of Clinical and Aesthetic Dermatology, 2020The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Ingredients
Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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