# Medik8 Liquid Peptides for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medik8](https://lovi.care/skincare/it/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for wrinkles and fine lines, as Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 support collagen production, while Glycerin and Hyaluronic Acid provide excellent humectant action for your normal skin.
- The formulation is safe for your normal skin due to the absence of prohibited or harsh ingredients.
- This product provides visible anti-aging effects with its plumping and firming properties.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Users consistently praise this serum as a "Botox in a bottle" alternative that delivers immediate hydration and visible plumping, particularly for fine lines on the forehead and around the eyes. It is widely celebrated for its ability to smooth skin texture and restore bounce to dry or mature skin without causing irritation, making it a staple for those targeting early to advanced signs of aging.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Elegant, lightweight texture (often mentioned)
- Liked: Visibly plumps and smooths (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: Packaging fragility (sometimes noted)
- Disliked: Results require patience (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medik8 Liquid Peptides work for mature skin?

Medik8 Liquid Peptides works moderately well for mature skin, helping to smooth fine lines and plump the skin with peptides and hydrating ingredients. To fit mature skin even better, a product needs exceptionally safe, irritation-free formulas with high concentrations of potent antioxidants, skin-repairing components, and high-quality ingredients that target aging effectively.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for mature skin?

Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 help smooth fine lines by supporting collagen production, while Glycerin and Hyaluronic Acid keep your skin hydrated. To fit mature skin even better, this type of product also needs high concentrations of potent antioxidants and skin-repairing ingredients.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Argireline do for mature skin?

Argireline helps smooth out lines and makes mature skin look firmer and less rough when used twice a day. It may also help keep skin hydrated, though its penetration is naturally limited.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Palmitoyl Tripeptide-1 do for mature skin?

Palmitoyl tripeptide-1 helps improve firmness, smooths out wrinkles, and enhances skin brightness when used as part of an anti-aging routine. Studies show that when applied at night or combined with complementary peptides, it supports collagen production to make mature skin look more firm and elastic.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and gives extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the peptide serum first and following with your retinol product. This helps firm and plump your skin while supporting collagen production, though mature skin often responds better to formulas with higher concentrations of specialized anti-aging ingredients.

### How often should I use it?

You can use this treatment in the evening as part of your routine for mature skin. This product of this type needs firming peptides like Acetyl Hexapeptide-8 and smoothing ingredients to better target lines and wrinkles on your skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin due to the absence of heavy oils and harsh ingredients. To properly care for mature skin, a product of this type needs firming peptides like Acetyl Hexapeptide-8 and hydrating ingredients like Hyaluronic Acid to smooth fine lines and keep the skin soft.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

- Amazon.it: €109.17 (https://www.amazon.it/dp/B0DSJNWVV6?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €56.80 (https://www.lookfantastic.it/p/medik8-liquid-peptides-30ml/12309458/)
- Notino: €67.00 (https://www.notino.it/medik8/liquid-peptides-siero-antirughe/p-16088423/)
Prices checked 16 Oct – 1 Nov 2026.

## Ingredients

Water, Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Hyaluronic Acid, Lecithin, Caprylyl Glycol, Disodium Edta, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/liquid-peptides/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/liquid-peptides/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/liquid-peptides/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medik8/liquid-peptides/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medik8/liquid-peptides/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/liquid-peptides/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/mature-skin