Medik8 Bakuchiol Peptides for skin with dark spots

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Questions and answers

What the research says

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Topical application of undecylenoyl phenylalanine 2% significantly lightened solar lentigines on the hands compared to vehicle control in 30 patients, with moderate to marked improvement and minimal side-effects.

  Clinical and Experimental Dermatology, 2010

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Emulgels containing Perilla frutescens seed oil, Moringa oleifera seed oil, and mixed seed oil microemulsions exhibit good stability, lack of cytotoxicity in PBMC, and no skin irritation or allergic reactions in human subjects.

  Polymers, 2022

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.

  Health Science Reports, 2025

• Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects.

  International Journal of Cosmetic Science, 2014

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• Moringa seed oil stimulated sebaceous lipogenesis, reduced pro-inflammatory cytokine secretion, and exhibited a low n-6/n-3 index in cultured human SZ95 sebocytes compared to untreated cells.

  International Journal of Molecular Sciences, 2023

• Topical Moringa oleifera seed oil and its main constituent oleic acid reduced acute and chronic skin inflammation and epidermal hypertrophy in mice through glucocorticoid receptor activation without dexamethasone-like adverse effects on organ weights.

  Journal of Ethnopharmacology, 2020

Ingredients

Caprylic Capric Triglyceride, Bakuchiol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Plukenetia Volubilis Seed Oil, Centella Asiatica Leaf Extract, Eclipta Prostrata Extract, Krameria Triandra Root Extract, Undecylenoyl Phenylalanine, Olea Europaea Oil Fruit Olive Oil Fruit, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Corallina Officinalis Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Tocopherol, Solanum Melongena Fruit Extract, Aloe Barbadensis Flower Extract, Jojoba Seed Oil, Curcuma Longa Root Extract, Ocimum Basilicum Leaf Extract Flower, Ocimum Sanctum Leaf Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.