# Mediheal A:PE Protain Mask for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Mediheal](https://lovi.care/skincare/it/brands/mediheal)
Category: [Face masks](https://lovi.care/skincare/it/best/face-masks)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few nourishing masks fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by the combination of niacinamide for barrier repair and glycerin for humectant action, which are ideal for maintaining skin hydration and health.
- The product offers relevant benefits for your redness and irritation with ingredients like Centella Asiatica Extract and Dipotassium Glycyrrhizate, which are moderately effective for soothing sensitive skin.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Hyaluronate, Centella Asiatica Extract, Squalane

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with dry, sensitive, or compromised skin barriers report excellent outcomes, praising the mask for its rich, creamy essence that deeply moisturizes and calms redness. While highly effective for soothing irritation and flattening pimples, the heavy, milky texture can be too rich or sticky for those with oily or acne-prone skin.

- Liked: Rich hydration (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Soft adherent sheet (often mentioned)
- Disliked: Heavy sticky finish (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Disliked: Artificial fragrance (rarely noted)
- Disliked: Fit issues (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start by using the sheet mask 3 times a week and increase if your skin feels good.
- Apply the sheet mask right after cleansing and toning, but always before your daily moisturizer or SPF.
- Unfold the sheet mask and gently press it onto your face, avoiding any harsh rubbing. Leave it on for ten to fifteen minutes.
- For sensitive skin, apply the sheet mask on completely dry skin to ensure better comfort and tolerance.
- Always avoid the delicate eye area and do a quick patch test before your very first use.
- Video: https://storage.pora.ai/cf9cbc1593b43309df7ca9cfe4fbbdae.mp4

## Questions and answers

### What makes the Mediheal A:PE Protain Mask a great fit for sensitive skin?

This mask is a great fit because it uses Centella Asiatica Extract and Dipotassium Glycyrrhizate to help calm redness and irritation on sensitive skin. It also has a very safe formula with soothing ingredients and no harsh irritants.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this mask a good fit for sensitive skin?

This mask is a great fit for sensitive skin because it contains Centella Asiatica Extract and Dipotassium Glycyrrhizate, which help soothe redness and irritation. It also features niacinamide and glycerin to support barrier repair and keep skin hydrated, while having an excellent safety profile without harsh ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hydrolyzed Collagen do for sensitive skin?

Hydrolyzed Collagen helps soothe sensitive skin by calming irritation and keeping it deeply hydrated. It supports the skin barrier so dry, easily upset skin feels much softer and more comfortable with regular use.
Sources: [International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34638528/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/)

### Where does this mask go in a skincare routine for sensitive skin?

This mask goes in your weekly routine after the cleanser and enzyme powder, and before your treatment and moisturizer. It is a great fit for sensitive skin because it is very unlikely to cause irritation and includes soothing ingredients that help calm redness.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this mask with retinol, and in what order?

You can use this nourishing mask with retinol by applying the mask first in your routine and following it with your retinol treatment. This combination is unlikely to cause irritation for sensitive skin due to the soothing ingredients and lack of harsh components.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this mask?

This nourishing mask is a great fit for your sensitive skin and is used weekly as part of your routine. It has an excellent safety profile with no risks of irritation, helping to keep sensitive skin calm and comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this mask clog pores, cause breakouts or purging for sensitive skin?

This mask is a great fit and has an excellent safety profile for sensitive skin, meaning it is unlikely to clog pores or cause irritation. Its soothing ingredients help calm the skin without triggering breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this mask fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [Anua Heartleaf 77% Soothing Sheet Mask](https://lovi.care/skincare/it/p/anua/heartleaf-77-soothing-sheet-mask/for/sensitive-skin) — Superior fit — €26.00 at Amazon
- [Mediheal Watermide Essential Mask](https://lovi.care/skincare/it/p/mediheal/watermide-essential-mask/for/sensitive-skin) — High fit — €34.27 at Amazon
- [ROUND LAB Pine Calming Cica Mask](https://lovi.care/skincare/it/p/round-lab/pine-calming-cica-mask/for/sensitive-skin) — High fit — €39.47 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

- Amazon.it: €31.77 (https://www.amazon.it/dp/B0DYMS2K3M?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Niacinamide, Propylene Glycol, Cetearyl Alcohol, Squalane, Glycerin, Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid, Dipotassium Glycyrrhizate, Lactobacillus Eriodictyon Californicum Extract Ferment, Lactobacillus Soybean Extract Ferment, Centella Asiatica Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Vitex Agnus Castus Extract, Chamomilla Recutita Extract Matricaria Extract, Chamaecyparis Obtusa Leaf Extract, Peg-12 Dimethicone, Hydroxyethyl Urea, Willow Bark Extract, Scutellaria Baicalensis Root Extract, Betaine, Bifida Ferment Filtrate, Pentylene Glycol, Xylitylglucoside, Adenosine, Anhydroxylitol, Leontopodium Alpinum Callus Culture Extract, Xylitol, Dimethicone, Extract Milk Protein, Tocopheryl Acetate, Hydrolyzed Collagen, Sodium Hyaluronate, Glucose, Portulaca Oleracea Extract, Butylene Glycol, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Acetyl Hexapeptide-8, Phenoxyethanol, Copper Tripeptide-1, Ethylhexylglycerin, Disodium Edta, Carbomer, 1,2-Hexanediol, Zanthoxylum Piperitum Fruit Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/a-pe-protain-mask/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/a-pe-protain-mask/for/sensitive-skin