# Medicube Zero Pore One-Day Cream for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medicube](https://lovi.care/skincare/it/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product effectively minimizes pores and smooths texture with salicylic acid and niacinamide, which also help regulate oil production in your oily areas and provide mild exfoliation for your acne-prone skin.
- Witch hazel extract and panthenol offer soothing benefits, complementing the active ingredients and ensuring comfort for your skin.
- The formulation is safe for your acne-prone skin, free from harsh ingredients and containing beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/oily-acne-prone-skin): High

## Key ingredients

Panthenol, Bha, Glycerin, Niacinamide, Sodium Hyaluronate

## What the research says

- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle. ([Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users with oily and combination skin appreciate this cream's lightweight, non-sticky texture that effectively balances moisture and controls sebum. Many report smoother skin texture and a reduction in the appearance of pores over time, though some find the "one-day" pore-shrinking claims to be exaggerated, suggesting it functions better as a daily moisturizer than a rapid treatment.

- Liked: Lightweight texture (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Oil control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Unsanitary packaging (sometimes noted)
- Liked: Pore maintenance (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes medicube Zero Pore One-Day Cream a great fit for acne-prone skin?

This cream is a great fit because it contains salicylic acid and niacinamide, which help minimize pores, smooth texture, and manage oil in oily areas while providing mild exfoliation for acne-prone skin. Witch hazel extract and panthenol add soothing benefits to keep your skin comfortable and calm.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for acne-prone skin?

Salicylic acid and niacinamide make this cream a great fit by providing mild exfoliation and helping to regulate oil production for acne-prone skin. Additionally, panthenol and witch hazel extract offer soothing benefits that keep your skin feeling calm and comfortable.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### What does Panthenol do for acne-prone skin?

Panthenol helps acne-prone skin by soothing redness and supporting the skin barrier while keeping skin hydrated. It is unlikely to cause irritation and works well to calm angry spots without clogging pores.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/)

### What does Bha do for acne-prone skin?

BHA helps clear acne-prone skin by clearing out pores to reduce both inflammatory and non-inflammatory breakouts. It also helps calm redness and lower oil production, and is unlikely to cause harsh side effects when used regularly.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Where does this cream go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. Using it at this time helps keep your skin calm and safe from sun exposure while it smooths texture and manages breakouts.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it after your retinol treatment to help keep your acne-prone skin calm and comfortable. Using a gentle moisturizer alongside strong treatments is unlikely to cause irritation and may help support your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this cream?

You can use this moisturizing treatment in your evening routine, applying it after cleansing and toning. Daily application is a great fit for your acne-prone skin, helping to minimize pores and smooth texture while keeping your skin calm and comfortable.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause breakouts on acne-prone skin because it contains salicylic acid and niacinamide to help clear pores and control oil. Soothing ingredients like panthenol and witch hazel extract help keep your skin calm, though a small number of users may experience mild irritation.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is designed for facial use, so applying it around the eyes or on the body requires caution due to differences in skin thickness and sensitivity across body regions. While the formulation avoids harsh ingredients and includes soothing components like panthenol, the active ingredients like salicylic acid are primarily intended to manage facial pores and texture rather than the very thin skin around the eyes.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — €92.92 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — €12.09 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €17.70 (https://www.amazon.it/dp/B0BCK9G74Q?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €24.90 (https://www.notino.it/medicube/zero-pore-one-day-cream-crema-idratante-leggera-per-chiudere-i-pori/p-16299752/)
Prices checked 10 Oct – 2 Nov 2026.

## Ingredients

Water, Glycerin, Witch Hazel Extract, Panthenol, Allantoin, Melaleuca Alternifolia Tree Leaf Extract, Butylene Glycol, 12-Hexanediol, Hyaluronic Acid, Salicylic Acid, Niacinamide, Vitis Vinifera Fruit Extract Grape Fruit Extract, Camellia Sinensis Leaf Extract, Peptides, Sorbitan Olivate, Beta-Glucan
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin