# Medicube One Day Exosome Shot 7500 for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medicube](https://lovi.care/skincare/it/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your oily skin, as niacinamide and gluconolactone help regulate oil production and exfoliate pores, though ingredients like glycerin and panthenol provide general hydration that is less relevant to your primary concern of oily shine.
- The inclusion of Lactobacillus Extracellular Vesicles and Betaine Salicylate offers good support for improving skin texture and tone, but the overall formulation does not directly target the reduction of oily shine.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin): Average

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Adenosine, Betaine Salicylate, Oenothera Biennis Flower Extract

## What the research says

- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))

## Why other serums fit oily skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Painful application (mostly mentioned)
- Liked: Fast/overnight results (often mentioned)
- Liked: Visible pore reduction (often mentioned)
- Liked: Enhanced product absorption (sometimes noted)
- Disliked: Not for sensitive skin (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: High price point (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Exosome Shot 7500 work for oily skin?

Medicube One Day Exosome Shot 7500 offers moderate benefits for oily skin because ingredients like niacinamide and gluconolactone help regulate oil and exfoliate pores. However, it includes heavy hydration that is less relevant to oily shine, so a treatment for this skin needs ingredients that specifically target excess oil, control sebum, and reduce enlarged pores alongside soothing and barrier-supporting components.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for oily skin?

Niacinamide and gluconolactone make this serum a good fit for oily skin because they help regulate oil production and exfoliate pores. A treatment of this type needs effective ingredients like niacinamide to control sebum production and manage oily shine, alongside soothing components and light hydration that keep the skin comfortable without clogging pores.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### What do Lactobacillus Extracellular Vesicles do for oily skin?

Lactobacillus extracellular vesicles help calm irritated skin and support a balanced skin barrier. They are unlikely to clog pores and may reduce redness or inflammation in oily skin types.
Sources: [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/), [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41175997/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. Oily skin works best with products that directly target excess oil control and pore clearing using ingredients like salicylic acid and niacinamide.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying this product first and waiting for it to absorb before applying your retinol. This approach helps minimize potential irritation while allowing both ingredients to work effectively on your skin.

### How often should I use this serum?

Start by using this treatment once a week in your evening routine, and if your skin tolerates it well and shows good results, you may carefully use it more often. This product of this type needs ingredients that directly target oil production and reduce oily shine to work best for oily skin.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to clog pores or cause breakouts on oily skin, as it is safe with no harsh ingredients, though oily skin of this type needs targeted oil-controlling ingredients like niacinamide and salicylic acid to best manage shine.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €37.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/oily-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €17.99 (https://www.amazon.it/dp/B0D137TMRB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €21.56 (https://www.lookfantastic.it/p/medicube-one-day-exosome-shot-pore-ampoule-7500-30ml/16858544/)
- Notino: €34.90 (https://www.notino.it/medicube/one-day-exosome-shot-pore-ampoule-7500-siero-rivitalizzante-intenso-contro-le-imperfezioni-della-pelle/p-16313460/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/oily-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-7500/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/oily-skin