# Medicube One Day Exosome Shot 2000 for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medicube](https://lovi.care/skincare/it/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent suitability for your combination skin, as Lactobacillus Extracellular Vesicles and Niacinamide work to repair the skin barrier and regulate sebum production, addressing your oily shine.
- The inclusion of Betaine Salicylate and Glycerin provides effective chemical exfoliation and hydration, supporting overall skin health and regeneration.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))
- Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline. ([Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/15608997/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation. ([Chemical & Pharmaceutical Bulletin, 2010](https://pubmed.ncbi.nlm.nih.gov/20190449/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Prickly/tingling sensation (mostly mentioned)
- Liked: Pore tightening (often mentioned)
- Liked: Blackhead reduction (sometimes noted)
- Liked: Fast results (sometimes noted)
- Disliked: Can be drying (rarely noted)
- Disliked: Skin irritation/breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Exosome Shot 2000 a great fit for combination skin?

Medicube One Day Exosome Shot 2000 is a great fit for combination skin because Lactobacillus Extracellular Vesicles and Niacinamide help repair your skin barrier and control oily shine. Betaine Salicylate and glycerin also provide gentle chemical exfoliation and hydration to keep your skin healthy and smooth with an excellent safety profile.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a good fit for combination skin?

Lactobacillus Extracellular Vesicles and Niacinamide make this treatment a great fit by repairing your skin barrier and regulating oily shine. Additionally, Betaine Salicylate and Glycerin help by providing gentle exfoliation and deep hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Lactobacillus Extracellular Vesicles do for combination skin?

Lactobacillus extracellular vesicles help balance combination skin by supporting the skin barrier and calming redness. This ingredient may also help soothe dry patches while keeping the skin smooth and comfortable.
Sources: [World Journal of Microbiology & Biotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42804019/), [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, applied after your cleansing toner and before your moisturizer. You can use it once a week to start, and if your skin tolerates it well and shows good results, you may carefully use it more often.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol, but it is best to apply it on separate nights to avoid overwhelming your skin. Using them together may lead to unwanted dryness or irritation, so alternating days helps keep your skin calm and balanced.

### How often should I use this treatment?

Use this treatment in your evening routine once a week to start, and if your skin feels comfortable and you see good results, you can carefully use it more often. It is very suitable for combination skin because it helps repair the skin barrier, control oily shine, and provide gentle chemical exfoliation without irritation.

### Can this treatment clog pores, cause breakouts or purging for combination skin?

Medicube One Day Exosome Shot 2000 is unlikely to clog pores or cause breakouts on your combination skin. The product has a low risk of skin irritation and breakouts, though it may cause a prickly or tingling sensation when applied.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €16.60 (https://www.amazon.it/dp/B0D16L5F2M?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €20.90 (https://www.notino.it/medicube/one-day-exosome-shot-2000-siero-rigenerante-intenso-per-una-pelle-luminosa-e-liscia/p-16313459/)
- Lookfantastic: €22.31 (https://www.lookfantastic.it/p/medicube-one-day-exosome-shot-pore-ampoule-2000-30ml/16858542/)
Prices checked 18 Oct – 3 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/combination-skin