# Medicube EXOSOME CICA CALMING PAD for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medicube](https://lovi.care/skincare/it/brands/medicube)
Category: [Toners](https://lovi.care/skincare/it/best/toners)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other toners fit it better.

## Why this fit

- Offers moderate soothing for your oily skin as Exosome Cica and niacinamide help reduce redness and calm irritation, supporting your concerns with acne and blemishes.
- Niacinamide provides some oil control benefits for your oily skin, though stronger sebum-regulating ingredients would enhance overall effectiveness.
- The product is safe for your skin, with no irritation risks due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Exosome Cica, Tree, Niacinamide

## What the research says

- Topical application of 100% tea tree oil significantly reduced histamine-induced mean weal volume compared to control in twenty-seven volunteers. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12452873/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Dermocosmetic loaded with plant extract significantly improved skin texture and surface parameters including roughness, scaliness, smoothness, and wrinkles compared to a base without extract in Asian male volunteers over three months. ([Pakistan Journal of Pharmaceutical Sciences, 2020](https://pubmed.ncbi.nlm.nih.gov/32276894/))
- A cosmetic cream containing Harungana madagascariensis plant extract induces similar anti-aging effects to a retinol-containing cream on 46 human subjects, improving wrinkles, ptosis, color homogeneity, smoothness, plumpness, firmness, and elasticity. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37155516/))
- An OTC topical formulation containing a plant extract complex improved skin extensibility and firmness significantly (P < 0.02) compared to placebo in 20 volunteers, with no adverse reactions. ([International Journal of Cosmetic Science, 2000](https://pubmed.ncbi.nlm.nih.gov/18503475/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## Why other toners fit oily acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

Based on a very large amount of data, users with sensitive and acne-prone skin frequently praise these pads for their immediate cooling and redness-reducing effects, often noting significant relief from facial heat and irritation. While most find them highly hydrating and effective for smoothing skin texture, a minority of users felt they were less effective for active blemishes or found the pad material slightly rough.

- Liked: Rapid soothing cooling (mostly mentioned)
- Liked: Hydrating non-sticky (often mentioned)
- Liked: Generous essence (sometimes noted)
- Liked: Gentle exfoliation (sometimes noted)
- Liked: High adherence (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Ineffective on acne (rarely noted)
- Disliked: Pad texture rough (rarely noted)
- Disliked: Strong scent (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using your soothing toner 3 times a week and move to daily use if your skin tolerates it well.
- Apply your soothing toner after cleansing, and before your moisturizer or SPF . This helps prepare your oily skin for the next steps.
- Gently press 2-3 drops of the soothing toner into your skin with your hands. Avoid rubbing the product to keep your skin calm.
- Apply the soothing toner on clean and slightly damp skin to help with better absorption . This keeps your skin feeling fresh and comfortable.
- Always do a patch test before first use to check for any sensitivity. Avoid the eye area and stop use if irritation occurs.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### How well does medicube Exosome Cica Calming Pad work for oily acne-prone skin?

This soothing toner offers moderate soothing for oily skin as exosome cica and niacinamide help reduce redness and calm irritation, supporting concerns with acne and blemishes. Niacinamide provides some oil control, but an oily skin type needs stronger oil-controlling ingredients and hydrating components that keep skin balanced without being overly dry.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12452873/)

### Which ingredients make this toner a good fit for oily acne-prone skin?

Exosome Cica, tea tree, and niacinamide make this toner a good fit by helping calm irritation, reduce redness, and provide moderate oil control. To best match oily skin, this type of product also needs stronger oil-controlling agents and hydrating ingredients that balance the skin without causing excess oiliness.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12452873/)

### What do Exosomes do for oily acne-prone skin?

Exosomes help calm angry breakouts and reduce the swelling of active acne while also fading leftover dark spots and smoothing out acne scars. They work by soothing inflammation deep in the skin and supporting a more balanced recovery, though improper deeper injections may carry a risk of localized irritation.
Sources: [The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/), [FASEB Journal, 2026](https://pubmed.ncbi.nlm.nih.gov/41474360/)

### What does Tea Tree Oil do for oily acne-prone skin?

Tea tree oil helps target blemishes and calm redness on oily, acne-prone skin by fighting blemish-causing bacteria and reducing inflammation. It may significantly improve pimples and overall skin clarity, though it can have a slower start and a safe profile when used correctly.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [The Medical Journal of Australia, 1990](https://pubmed.ncbi.nlm.nih.gov/2145499/)

### Where does this toner go in a skincare routine for oily acne-prone skin?

This toner fits into an evening routine as a cleansing step after makeup removal and a cleanser, while other products fit oily acne-prone skin better by needing stronger oil-controlling ingredients.

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol, applying the toner first to calm your skin before your retinol treatment. It is unlikely to cause irritation due to its soothing ingredients, though oily acne-prone skin still needs stronger oil-controlling ingredients for best results.

### How often should I use this toner?

You can use this soothing toner regularly as part of your daily routine since it is safe and gentle for oily, acne-prone skin. Because it works moderately well, this skin type needs stronger oil-controlling ingredients like salicylic acid or zinc alongside soothing components to fully manage shine and breakouts.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12452873/)

### Can this toner clog pores, cause breakouts or purging for oily acne-prone skin?

This toner is unlikely to clog pores or cause breakouts for your oily acne-prone skin, as it has a safe formula with soothing ingredients and no harsh components. However, because it only offers moderate oil control, an oily acne-prone skin type needs stronger sebum-regulating ingredients to fully prevent breakouts.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12452873/)

## Alternatives for oily acne-prone skin

- [belif Problem Solution Toner](https://lovi.care/skincare/it/p/belif/problem-solution-toner/for/oily-acne-prone-skin) — Superior fit — €41.84 at Amazon
- [Medicube Super Cica Pad](https://lovi.care/skincare/it/p/medicube/super-cica-pad/for/oily-acne-prone-skin) — High fit — €45.20 at Amazon
- [medicube Exosome Cica Calming Toner](https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-toner/for/oily-acne-prone-skin) — High fit — €13.49 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — €40.49 at Amazon

## Where to buy

- Amazon.it: €45.20 (https://www.amazon.it/dp/B0DFG4MRC9?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €26.50 (https://www.notino.it/medicube/exosome-cica-calming-pad-cuscinetti-tonificanti-con-effetto-lenitivo/p-16359263/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Exosome Cica, Tree, Niacinamide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin