# MEDI THERAPY Retinal Skin Booster for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [MEDI THERAPY](https://lovi.care/skincare/it/brands/medi-therapy)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for minimizing fine lines and wrinkles, as retinal promotes skin regeneration and Centella Asiatica provides soothing benefits for your normal skin.
- Niacinamide further supports skin health by offering anti-inflammatory action, contributing to overall skin comfort.
- The product is safe for your normal skin due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/oily-acne-prone-skin): Average

## Key ingredients

Retinal, Centella Asiatica, Niacinamide

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

Based on a very large amount of data, users with sensitive, acne-prone, and aging skin report this product is gentle and effective, improving skin texture and hydration without irritation. Many users notice a radiant glow, reduced pore visibility, and smoother skin. Some users with very dry skin mention needing additional moisturization.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Hydrating & lightweight (often mentioned)
- Liked: Improves texture & pores (often mentioned)
- Liked: Fades acne & marks (sometimes noted)
- Liked: Great value (sometimes noted)
- Disliked: Dry skin needs more (rarely noted)
- Disliked: Mild stinging (rarely noted)
- Disliked: No visible change (rarely noted)
- Disliked: Packaging quality (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MEDI THERAPY Retinal work for mature skin?

MEDI THERAPY Retinal Skin Booster works moderately well for mature skin by helping to smooth fine lines and calm the skin. To work best for this skin, a treatment needs high concentrations of potent antioxidants, deep hydrating components, and skin-repairing ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this serum a good fit for mature skin?

Retinal, Centella Asiatica, and Niacinamide make this serum a good fit for mature skin by helping smooth fine lines, calming the skin, and supporting overall skin health. To fit this skin type even better, products of this type need high-quality anti-aging ingredients, strong antioxidants, and deeply hydrating components.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Retinal do for mature skin?

Retinal helps smooth fine lines, improve uneven skin tone, refine texture, and tighten pores on mature skin. It may also boost skin thickness and elasticity over time while keeping irritation low compared to stronger options.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30027612/)

### What does Centella Asiatica do for mature skin?

Centella asiatica helps mature skin by boosting moisture, keeping it smooth, and supporting collagen to make skin look firmer and less wrinkled. It also helps calm redness and protect skin from daily stress and aging.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/), [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing toner and before moisturizer, as active serums fit best at night for simplicity and safety around sun exposure. Mature skin of this type needs products containing retinal, Centella Asiatica, and niacinamide to help soften fine lines and soothe the skin.

### Can I use it with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in your morning routine and this treatment at night, as using them separately helps keep your skin calm and comfortable. To better suit mature skin, this type of product also needs ingredients that deeply boost firmness and smooth fine lines.

### How often should I use this serum?

This treatment works well in the evening routine, and a product of this type for mature skin needs smoothing ingredients like retinoids along with calming components like Centella Asiatica to soften fine lines safely.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can it clog pores, cause breakouts or purging for mature skin?

MEDI THERAPY Retinal Skin Booster is unlikely to clog pores or cause breakouts on mature skin, though the retinal may cause mild initial purging as skin cell turnover speeds up. A product for this skin needs gentle exfoliating ingredients and soothing plant extracts like Centella Asiatica to keep pores clear while maintaining comfort.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Retinal, Centella Asiatica, Niacinamide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medi-therapy/retinal-skin-booster/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medi-therapy/retinal-skin-booster/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medi-therapy/retinal-skin-booster/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medi-therapy/retinal-skin-booster/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medi-therapy/retinal-skin-booster/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medi-therapy/retinal-skin-booster/for/mature-skin