# Medi-Peel Peptide 9 Volume Tox Cream for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Medi-Peel](https://lovi.care/skincare/it/brands/medi-peel)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other moisturizers fit it better.

## Why this fit

- This cream offers moderate hydration and anti-aging benefits for your oily skin, with sodium hyaluronate and adenosine working to smooth fine lines and provide moisture. However, it lacks sufficient ingredients to directly manage your primary concerns of acne, blemishes, and breakouts, or to effectively control oiliness.
- While the formula is generally safe for your oily skin due to soothing ingredients like sunflower seed oil and magnolia officinalis bark extract, its primary function is hydration rather than addressing your specific skin issues.
- The product has a good safety profile with no reported irritation risks for oily skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Peptide 9, Sodium Hyaluronate, Copper Tripeptide-1, Hydrolyzed Collagen, Adenosine

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Parthenolide and magnolol, as NF-kappaB inhibitors, effectively blocked UVB-induced gene expression, production of MMP-1 and bFGF, and proliferation of keratinocytes and melanocytes. ([Current Drug Metabolism, 2010](https://pubmed.ncbi.nlm.nih.gov/20540695/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## Why other moisturizers fit oily acne-prone skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on limited data, users highly praise this cream for its ability to deeply hydrate and plump the skin, resulting in a softer, bouncier, and glowing complexion, making it a favorite for aging and dry skin types. Its lightweight texture absorbs quickly without residue. While many appreciate its anti-aging benefits and pleasant scent, some users with acne-prone skin report breakouts, and a few find the moisture insufficient for very dry winter conditions.

- Liked: Hydrates and plumps (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Expensive for amount (rarely noted)
- Disliked: Not enough moisture (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Medi-Peel Peptide 9 Volume Tox Cream work for oily acne-prone skin?

Medi-Peel Peptide 9 Volume Tox Cream works moderately well for oily acne-prone skin by offering safe hydration and smoothing fine lines with sodium hyaluronate and adenosine, though it lacks targeted blemish-fighting ingredients. This type of skin needs lightweight formulas that control oil, clear breakouts, and support the skin barrier without clogging pores.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Which ingredients make this cream a good fit for oily acne-prone skin?

Sodium hyaluronate and adenosine help smooth fine lines and provide moisture, while sunflower seed oil and magnolia officinalis bark extract offer soothing benefits that are generally safe for your oily skin. Oily acne-prone skin needs a moisturizing treatment with powerful hydrating and repairing ingredients to manage acne and blemishes while effectively controlling oiliness without clogging pores.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### What does Peptide 9 do for oily acne-prone skin?

Peptide 9 helps oily acne-prone skin by strengthening the skin barrier and reducing excess surface oil and breakouts. Regular topical use helps keep skin smooth and calm while minimizing the appearance of blemishes.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32697858/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this cream go in a skincare routine for oily acne-prone skin?

This moisturizing treatment goes in the moisturizer step, used after your hydrating toner in the morning and after your treatment step in the evening. It provides moderate hydration and helps smooth fine lines for your oily skin, though oily acne-prone skin needs a product that also manages breakouts and controls oiliness.

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the retinol first and following it with this cream to help keep your skin soft and minimize dryness. Using a moisturizer alongside treatments like retinol is unlikely to cause irritation and may help your skin tolerate the routine better. This skin type needs a product that also controls oil and manages breakouts.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing treatment works well when used twice a day as part of your routine. Daily application helps improve skin moisture and keeps your oily skin feeling soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream may cause breakouts, as reviewers report this issue, and the formula lacks ingredients to control oil or manage acne. Oily acne-prone skin needs a moisturizing treatment with oil-balancing and blemish-clearing ingredients like salicylic acid or niacinamide.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, but it is formulated primarily for facial care. Because the skin around your eyes is particularly thin, a product of this type needs lightweight hydrators and gentle soothing ingredients to avoid irritation while providing moisture.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/oily-acne-prone-skin) — Superior fit — €12.09 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/oily-acne-prone-skin) — Superior fit — €18.06 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin) — High fit — €92.92 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — €40.49 at Amazon

## Where to buy

- Amazon.it: €22.58 (https://www.amazon.it/dp/B0CZJZKL31?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Methylpropanediol, Glycerin, Dimethicone, Cyclopentasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Pentaerythrityl Tetraisostearate, Peg-100 Stearate, Cetearyl Glucoside, Carbomer, Arginine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Trehalose, Helianthus Annuus Seed Oil Sunflower Seed Oil, Xanthan Gum, Adenosine, Polysorbate 80, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Glycine Soja Oil Soybean Oil, Desamido Collagen, Juniperus Communis Fruit Extract, Magnolia Officinalis Bark Extract, Eucalyptus Globulus Leaf Extract, Fructan, Hydrolyzed Collagen, Butylene Glycol, Hydrogenated Polyisobutene, Bixa Orellana Seed Oil, Propanediol, Sodium Hyaluronate Crosspolymer, Sorbitan Laurate, Propylene Glycol, Hydrolyzed Glycosaminoglycans, Nonoxynol-12, Phenoxyethanol, Chondrus Crispus Extract, Tocopherol, Hydroxyethylcellulose, Benzyl Glycol, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Hydrolyzed Elastin, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hexapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Raspberry Ketone, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- United Kingdom: https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin
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