# Mederma PM Intensive Overnight Scar Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Mederma](https://lovi.care/skincare/it/brands/mederma)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your normal skin, as Glycerin and Panthenol provide humectant action to support hydration, though it lacks sufficient occlusive and emollient ingredients for optimal skin hydration.
- The formulation includes Onion Bulb Extract and Copper Tripeptide-1 to improve skin texture and reduce the appearance of scars, offering general skincare benefits like hydration and soothing from Glycerin and Aloe Barbadensis Leaf that support your wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Dimethicone, Onion Bulb Extract, Copper Tripeptide-1, Aloe Barbadensis Leaf, Hydrolyzed Collagen

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Topical onion extract improved scar colour compared to silicon gel, while silicon gel was superior in decreasing scar height in 60 patients with hypertrophic and keloid scars, with the most effective results obtained from combining onion extract and silicon gel. ([Journal of Wound Care, 2007](https://pubmed.ncbi.nlm.nih.gov/17722521/))
- Silicone derivative plus onion extract gel reduced pain, itching, and pigmentation compared to placebo in patients after median sternotomy. ([International Wound Journal, 2012](https://pubmed.ncbi.nlm.nih.gov/22168750/))
- Topical 12% onion extract gel applied early on Pfannenstiel's cesarean section scars in Asians improved scar height and scar symptoms compared to placebo, with no significant difference in scar redness, pliability, or overall appearance. ([Dermatology Research and Practice, 2012](https://pubmed.ncbi.nlm.nih.gov/22924037/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## What reviewers say

Based on a very large amount of data, users report this cream is effective at softening and flattening scars from surgery, acne, and injuries with consistent use over months. Many appreciate the convenient, non-greasy application. However, results can take a long time to become noticeable, and a significant number of users find the scent unpleasant.

- Liked: Effective on scars (often mentioned)
- Disliked: Slow results (often mentioned)
- Disliked: Unpleasant smell (often mentioned)
- Liked: Convenient application (sometimes noted)
- Liked: Good absorption (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Price vs quantity (sometimes noted)
- Disliked: Skin reactions (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Mederma PM Intensive Overnight Scar Cream work for mature skin?

This cream works moderately well for mature skin, helping to hydrate and soothe fine lines while improving skin texture. However, it lacks sufficient sealing and softening ingredients for optimal skin hydration. A product for mature skin needs rich nourishing oils and peptides to lock in moisture and support firmness.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Which ingredients make this cream a good fit for mature skin?

Onion bulb extract and copper tripeptide-1 help improve skin texture and reduce the look of scars, while glycerin and aloe leaf help keep skin hydrated and calm. Mature skin of this type needs richer smoothing oils and heavier sealing ingredients to lock in moisture and keep the skin feeling soft and plump.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Dimethicone do for mature skin?

Dimethicone helps keep mature skin feeling soft and smooth while protecting the skin barrier. When used regularly, it may improve skin firmness and keep the surface hydrated throughout the day.
Sources: [Dermatologic Therapy, 2012](https://pubmed.ncbi.nlm.nih.gov/22913439/), [Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/)

### What does Onion Bulb Extract do for mature skin?

Onion bulb extract helps mature skin by providing powerful antioxidants that fight oxidative stress, calm inflammation, and support healthy wound healing and collagen production. These benefits help improve skin texture and reduce the signs of aging, making skin look smoother and more even.
Sources: [Naunyn-Schmiedeberg's Archives of Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39738831/)

### Where does this cream go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. To work best on mature skin, this type of product also needs rich sealing ingredients to lock in hydration and smooth fine lines.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following with this treatment in your evening routine. It is unlikely to cause irritation for normal skin due to its gentle safety profile, though this skin type needs extra rich moisturizing ingredients that lock in moisture and soften the skin.

### How often should I use this cream?

You can use this treatment cream in the evening as part of your nighttime routine. To work best for mature skin, a product of this type needs richer sealing and softening ingredients to lock in moisture.

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula without harsh ingredients. However, mature skin of this type needs richer protective and softening ingredients to keep it fully hydrated and smooth.

### Is this cream fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol and isopropyl alcohol).

## Alternatives for mature skin

- [Clarins Double Serum](https://lovi.care/skincare/it/p/clarins/double-serum/for/mature-skin) — High fit — €109.25 at Amazon
- [SKIN1004 Madagascar Centella Asiatica Ampoule](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin) — Average fit — €18.99 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Cetearyl Alcohol, Glycerin, C12-15 Alkyl Benzoate, Dicaprylyl Carbonate, Pentylene Glycol, Cyclomethicone, Arachidyl Alcohol, Alcohol, Behenyl Alcohol, Arachidyl Glucoside, Onion Bulb Extract, Copper Tripeptide-1, Aloe Barbadensis Leaf, Cetearyl Glucoside, Tocopheryl Acetate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Hydrolyzed Soy Protein, Glycine, Panthenol, Hydrolyzed Collagen, Peg-400, Arginine Hcl, Leucine, Lysine Hydrochloride, Alanine, Sodium Lactate, Aspartic Acid, Glucose, Glutamic Acid, Isopropyl Alcohol, Mannitol, Sorbitol, Tromethamine, Valine, Histidine Hydrochloride, Isoleucine, Phenylalanine, Tyrosine, Potassium Sorbate, Sodium Benzoate, Citric Acid, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mederma/pm-intensive-overnight-scar-cream/for/mature-skin