# Lancôme Rénergie H.P.N. 300-Peptide Cream for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Lancôme](https://lovi.care/skincare/it/brands/lancome)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for normal skin with ingredients like niacinamide and hydrolyzed hyaluronic acid, which help with barrier repair and hydration, but lacks specialized components to directly address your redness and irritation concerns.
- The presence of adenosine provides excellent anti-aging and smoothing effects, contributing to overall skin health.
- The product is safe for your sensitive skin, as it contains no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Sodium Hyaluronate, Niacinamide, Hydrolyzed Lupine Protein, Adenosine

## What the research says

- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin. ([The Journal of Dermatological Treatment, 2002](https://pubmed.ncbi.nlm.nih.gov/19753737/))

## What reviewers say

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

- Liked: Luxurious non-greasy texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging results (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant fragrance (sometimes noted)
- Liked: Refillable packaging (sometimes noted)
- Disliked: Heavy for oily skin (rarely noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Skin irritation (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for sensitive skin?

This cream works moderately well for sensitive skin, as it is safe and provides good hydration and smoothing effects, but it lacks targeted ingredients to directly calm redness and irritation. A product of this type needs soothing ingredients like fermented Centella Asiatica, Cica Ceramide, and nourishing oils to effectively calm redness and care for sensitive skin.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### Which ingredients make this cream a good fit for sensitive skin?

Niacinamide and sodium hyaluronate help keep sensitive skin calm and hydrated, while adenosine smooths and supports overall skin health safely. A product of this type needs soothing ingredients like fermented centella asiatica, cica ceramide, and nourishing oils to actively calm redness and irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### What do Peptides do for sensitive skin?

Peptides help support the skin barrier and improve the feel of sensitive skin by encouraging firmness and a smooth look. When paired with soothing and hydrating ingredients, peptide products are generally well tolerated and unlikely to cause irritation.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [Journal of Biomedical Materials Research, 1998](https://pubmed.ncbi.nlm.nih.gov/9457557/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this cream go in a skincare routine for sensitive skin?

This moisturizing treatment goes in the evening routine after cleansing and toning, followed by your usual moisturizer. Because this cream offers an average fit for sensitive skin, a better option for this skin type needs soothing and calming ingredients to directly address redness and irritation.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the treatment first and following with a moisturizer, or by using a barrier-enhancing moisturizer beforehand to help your skin tolerate the retinoid better. This product is safe for sensitive skin, but since it lacks specialized ingredients to directly address redness and irritation, sensitive skin generally needs a product with soothing components like ceramides or centella asiatica to keep the skin calm.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22648223/)

### How often should I use this cream?

You can safely use this cream as part of your evening routine, applying it once a day. This schedule helps keep your skin comfortable while avoiding potential irritation from daily overuse. Sensitive skin of this type needs soothing and calming ingredients like centella asiatica or green tea extract along with barrier-repairing ceramides to manage redness.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to cause breakouts or clogged pores for sensitive skin since it is safe and free of harsh irritants. However, because it works best for normal skin, sensitive skin needs a product that includes soothing ingredients to calm redness and irritation.

### Can I use this cream around the eyes or on my body?

This cream is safe to use around the eyes or on the body, but it is formulated primarily for facial care. To properly care for sensitive skin in these delicate areas, a product needs soothing plant extracts and gentle calming ingredients to prevent redness and irritation.

### Is this cream fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — €12.09 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/it/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — €16.22 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/it/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

- Amazon.it: €67.00 (https://www.amazon.it/dp/B0CMTB8RCH?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €59.57 (https://www.lookfantastic.it/p/lancome-renergie-h.p.n.-300-peptide-cream-50ml-refill/14205252/)
- Notino: €119.00 (https://www.notino.it/lancome/renergie-h-p-n-300-peptide-cream-confezione-regalo-da-donna-7134137/p-16360472/)
Prices checked 10 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin