# La Roche-Posay Toleriane Dermallergo Night for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, the squalane and niacinamide work synergistically to provide excellent moisturization and enhance barrier resilience, directly addressing your redness and irritation.
- The formulation's thoughtful inclusion of glycerin further supports hydration and soothes inflammation, making it a beneficial choice for your skin concerns.
- This product is safe for your sensitive skin, as it contains no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Spring Water, Squalane, Niacinamide, Butyrospermum Parkii Shea Butter, Dimethicone

## What the research says

- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Avène Thermal Spring Water significantly decreased postpeeling redness and reduced the overall sensitive scale of consumers by 47% compared to mineral-rich thermal spring water in human volunteers. ([Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Externally applied substances such as ceramides, hyaluronic acid, licorice extracts, dimethicone, petrolatum, and paraffin wax treat skin disease resulting from damage to the skin barrier. ([Clinics in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22507050/))

## What reviewers say

Users frequently report waking up to softer, plumper, and less irritated skin. A minority of users with oily or acne-prone skin found the formula too heavy or experienced breakouts.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Not hydrating enough (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Toleriane Dermallergo Night a great fit for sensitive skin?

La Roche-Posay Toleriane Dermallergo Night is a great fit because ingredients like squalane and niacinamide team up to deeply moisturize and strengthen your skin barrier while calming redness and irritation. Glycerin adds extra hydration to soothe inflammation, and the formula is designed without harsh ingredients so it is very unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for sensitive skin?

Squalane, niacinamide, glycerin, thermal spring water, shea butter, and dimethicone make this cream a great fit because they work together to deeply hydrate your skin, strengthen its barrier, and soothe redness and irritation. This thoughtful formula contains no harsh ingredients, making it very safe and unlikely to cause flare-ups.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Thermal Spring Water do for sensitive skin?

Thermal Spring Water helps calm sensitive skin by reducing redness, stinging, and overall skin sensitivity while boosting hydration. It is unlikely to irritate and is commonly used to soothe skin exposed to daily stressors and irritation.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/), [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### What does Squalane do for sensitive skin?

Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/)

### Where does this cream go in a skincare routine for sensitive skin?

This cream goes at the end of your evening routine as the final moisturizer step, right after your treatment. It helps lock in hydration and calms sensitive skin without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following it with this moisturizer in the evening. Using a moisturizing cream like this one helps calm the skin and supports your skin barrier, which may reduce the dryness and irritation often caused by retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this cream in your evening routine every day as a moisturizer to keep your skin soft and calm. Daily use helps improve skin moisture and strengthens the barrier.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts for your sensitive skin because it contains no harsh ingredients and has a very low rate of reviewer complaints about breakouts.

### Can I use this cream around the eyes or on my body?

Yes, you can use this cream around your eyes and on your body, though it is specially designed to keep sensitive facial skin calm and moisturized. Because the skin around the eyes is very thin, a gentle formula like this one helps hydrate without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — €12.09 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/it/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — €16.22 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/it/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

- Amazon.it: €22.59 (https://www.amazon.it/dp/B09XJWJM44?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €23.92 (https://www.lookfantastic.it/p/la-roche-posay-toleriane-dermallergo-night-cream-for-sensitive-skin-40ml/13528419/)
- Notino: €27.50 (https://www.notino.it/la-roche-posay/toleriane-dermallergo-crema-notte-per-pelli-sensibili/p-16128915/)
Prices checked 25 Oct – 4 Nov 2026.

## Ingredients

Water, Squalane, Butyrospermum Parkii Shea Butter, Glycerin, Dimethicone, Pentylene Glycol, Niacinamide, Sodium Hydroxide, Tocopherol, Adenosine, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Disodium Edta, Ethylhexylglycerin, Sodium Citrate, Xanthan Gum, Polysorbate 20
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
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- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
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- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin