# La Roche-Posay Toleriane Dermallergo Night for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, niacinamide helps regulate oil in your oily areas while squalane provides emollient action for your dry areas, addressing your acne, blemishes, and breakouts by supporting skin barrier function and reducing inflammation.
- The formula offers excellent moisturizing benefits due to the presence of squalane and glycerin, which hydrate and enhance barrier resilience.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Spring Water, Squalane, Niacinamide, Butyrospermum Parkii Shea Butter, Dimethicone

## What the research says

- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33038010/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## What reviewers say

Users frequently report waking up to softer, plumper, and less irritated skin. A minority of users with oily or acne-prone skin found the formula too heavy or experienced breakouts.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Not hydrating enough (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Roche-Posay Toleriane Dermallergo Night a great fit for acne-prone skin?

La Roche-Posay Toleriane Dermallergo Night is a great fit because niacinamide helps balance oil while squalane provides smoothing moisture for dry areas, supporting your skin barrier and calming breakouts. The formula is very safe and unlikely to cause irritation for your skin due to the absence of harsh ingredients.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Which ingredients make this cream a good fit for acne-prone skin?

This cream is a great fit for your acne-prone skin because niacinamide helps balance oil in oily areas while squalane softens dry patches. Together with glycerin, they support your skin barrier and reduce inflammation without the risk of irritation.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### What does Thermal Spring Water do for acne-prone skin?

Thermal spring water helps calm acne-prone skin by reducing dryness and stinging while improving overall tolerability when used alongside standard acne care. It may also help manage acne and reduce local irritation.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37338719/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does this cream go in a skincare routine for acne-prone skin?

This cream goes last in your morning routine before sunscreen, and last in your evening routine after any treatment serums. Using it this way helps keep your skin soft and hydrated while supporting your skin barrier against blemishes.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol by applying the retinol first and following it with this moisturizer. This helps keep your skin calm and hydrated while reducing the dryness and irritation that retinol may cause.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this cream?

This moisturizer is a great fit and is gentle enough to use twice a day in both your morning and evening routines. Daily use helps keep your skin calm and hydrated while supporting your skin barrier without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause breakouts for acne-prone skin because it has a very safe formula with no harsh or prohibited ingredients that trigger irritation. Squalane and niacinamide help support your skin barrier and calm inflammation without feeling heavy, though a small number of reviewers have noted minor breakouts.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Can I use this cream around the eyes or on my body?

Yes, you can use this cream around the eyes and on your body because its gentle formula features ingredients like squalane and glycerin that provide excellent moisturizing benefits and a very good safety profile with no irritation risks.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — €92.92 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — €12.09 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €22.59 (https://www.amazon.it/dp/B09XJWJM44?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €23.92 (https://www.lookfantastic.it/p/la-roche-posay-toleriane-dermallergo-night-cream-for-sensitive-skin-40ml/13528419/)
- Notino: €27.50 (https://www.notino.it/la-roche-posay/toleriane-dermallergo-crema-notte-per-pelli-sensibili/p-16128915/)
Prices checked 25 Oct – 4 Nov 2026.

## Ingredients

Water, Squalane, Butyrospermum Parkii Shea Butter, Glycerin, Dimethicone, Pentylene Glycol, Niacinamide, Sodium Hydroxide, Tocopherol, Adenosine, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Disodium Edta, Ethylhexylglycerin, Sodium Citrate, Xanthan Gum, Polysorbate 20
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin
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