# La Roche-Posay Pure Niacinamide 10 Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for normal skin, as niacinamide and glycerin provide anti-inflammatory and humectant actions respectively, supporting your skin's needs.
- The serum's phenylethyl resorcinol and niacinamide concentrations are beneficial for improving skin tone and brightening, though it lacks specialized ingredients to target your redness and irritation.
- The product is safe for your sensitive skin, containing no harsh ingredients and including soothing components like niacinamide and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Thermal Water, Sodium Hyaluronate, Phenylethyl Resorcinol, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Nano-microneedle-assisted phenylethyl resorcinol significantly reduced the melanin index in infraorbital dark circles compared to baseline and topical-only treatment in 20 female participants without serious adverse effects. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its ability to fade dark spots and improve skin texture, leaving skin feeling hydrated and plump. Many users with sensitive skin find it gentle. A significant number of reviewers dislike the strong floral fragrance and find the dropper bottle design inconvenient. Some users have experienced breakouts or pilling, and many note that the product is now discontinued or difficult to find.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Strong floral scent (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: Discontinued product (sometimes noted)
- Disliked: Messy dropper bottle (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Pilling issues (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does La Roche-Posay Pure Niacinamide 10 work for sensitive skin?

La Roche-Posay Pure Niacinamide 10 Serum works moderately well for sensitive skin, as it provides calming and hydrating benefits with a safe profile but lacks specialized ingredients to target redness and irritation. Sensitive skin of this type needs products containing effective soothing ingredients that specifically target redness and irritation while remaining gentle and free of harsh components.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide and glycerin make this serum safe and helpful for sensitive skin by soothing it and keeping it hydrated. To be a better fit for this skin type, a product of this type needs specialized ingredients that target redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Thermal Water do for sensitive skin?

Thermal water helps calm sensitive skin by reducing redness, stinging, and discomfort while strengthening the skin barrier against daily irritants. It is unlikely to cause irritation and may improve overall skin comfort and moisture levels.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine after your toner and before your moisturizer. It is safe for sensitive skin because it contains no harsh ingredients and includes soothing components, though a product for this skin also needs specialized ingredients to target redness and irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol. This product is safe for your sensitive skin and helps brighten your skin tone, but it lacks specialized ingredients to soothe redness and irritation, so this skin type also needs calming ingredients like centella asiatica or ceramides.

### How often should I use this serum?

This serum works well in the evening as part of your routine, though it may also be used in the morning or twice a day. It is safe for your sensitive skin with a low risk of irritation, but to care for your skin best, it needs extra soothing and redness-reducing ingredients.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts, as only a low number of reviewers mention that issue, but sensitive skin needs a fragrance-free formula with soothing ingredients that target redness and irritation.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Glycerin, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Dimethicone, Isopropyl Lauroyl Sarcosinate, Octyldodecanol, Peg-20 Methyl Glucose Sesquistearate, Tin Oxide, Sorbitan Oleate, Dimethiconol, Cetearyl Ethylhexanoate, Isohexadecane, Sodium Hyaluronate, Phenylethyl Resorcinol, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Disodium Edta, Isopropyl Myristate, Citric Acid, Xanthan Gum, Polysorbate 80, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Tocopherol, Phenoxyethanol, Mica, Ci 77891, Titanium Dioxide, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin
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- Italy: https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin
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