# La Roche-Posay Pure Niacinamide 10 Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone for your combination skin, as niacinamide and phenylethyl resorcinol help improve skin tone while niacinamide also aids in seboregulation.
- While glycerin provides humectant action suitable for combination skin, the formula's primary benefits are not directly targeted at managing oily shine.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Thermal Water, Sodium Hyaluronate, Phenylethyl Resorcinol, Glycerin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Nano-microneedle-assisted phenylethyl resorcinol significantly reduced the melanin index in infraorbital dark circles compared to baseline and topical-only treatment in 20 female participants without serious adverse effects. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its ability to fade dark spots and improve skin texture, leaving skin feeling hydrated and plump. Many users with sensitive skin find it gentle. A significant number of reviewers dislike the strong floral fragrance and find the dropper bottle design inconvenient. Some users have experienced breakouts or pilling, and many note that the product is now discontinued or difficult to find.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Strong floral scent (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: Discontinued product (sometimes noted)
- Disliked: Messy dropper bottle (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Pilling issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does La Roche-Posay Pure Niacinamide 10 work for combination skin?

La Roche-Posay Pure Niacinamide 10 Serum works moderately well for combination skin by helping even out skin tone and providing light moisture, though it is not primarily targeted at managing oily shine. A treatment of this type needs ingredients like zinc PCA or propolis to better balance oiliness and hydration for this skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/)

### Which ingredients make this serum a good fit for combination skin?

This serum fits combination skin because niacinamide and phenylethyl resorcinol help improve skin tone and balance oil, while glycerin provides soft hydration. Combination skin of this type needs ingredients like propolis or zinc PCA to better manage oily shine and keep the skin balanced and glowing.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Thermal Water do for combination skin?

Thermal water helps hydrate dry areas and calm redness on combination skin, making it feel more comfortable. It is unlikely to clog pores and can be used throughout the day whenever skin needs a quick refresh.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in your evening routine after cleansing and toning, and before your moisturizer. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment first and following with your retinol, or by using them on alternating nights to keep your skin calm. A combination routine for this skin type needs balancing ingredients like niacinamide and glycerin along with oil-controlling properties to properly manage oily shine.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is safe for your skin with no risks of irritation.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause irritation or breakouts on combination skin due to its safe ingredients, though reviewers occasionally mention minor breakouts. Combination skin generally benefits from lightweight formulas that balance oil and add moisture without heavy layers.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Glycerin, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Dimethicone, Isopropyl Lauroyl Sarcosinate, Octyldodecanol, Peg-20 Methyl Glucose Sesquistearate, Tin Oxide, Sorbitan Oleate, Dimethiconol, Cetearyl Ethylhexanoate, Isohexadecane, Sodium Hyaluronate, Phenylethyl Resorcinol, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Disodium Edta, Isopropyl Myristate, Citric Acid, Xanthan Gum, Polysorbate 80, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Tocopherol, Phenoxyethanol, Mica, Ci 77891, Titanium Dioxide, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin
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