# La Roche-Posay Mela B3 Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers moderate exfoliation and brightening for your oily skin, as niacinamide and capryloyl salicylic acid work to refine texture and improve radiance. Glycerin and dipotassium glycyrrhizate provide supportive hydration and soothing effects beneficial for acne and blemishes.
- The formulation is well-suited for oily skin due to ingredients that help regulate sebum and gently exfoliate.
- The product is safe for your skin, with no harsh ingredients and a good balance of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/mela-b3-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Niacinamide, La Roche-Posay Thermal Spring Water, Melasyl, Cystoseira Tamariscifolia Extract, Sodium Hyaluronate

## What the research says

- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33038010/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its lightweight, non-sticky texture and its ability to fade post-acne marks and sun spots over time. Many report brighter, more even skin tone within a few weeks. A notable portion of reviewers found the results slow or nonexistent for stubborn hyperpigmentation and complained about the strong floral fragrance.

- Liked: Good texture (mostly mentioned)
- Liked: Brightens skin (often mentioned)
- Liked: Fades dark spots (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: High price (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes La Roche-Posay Mela B3 Serum a great fit for oily acne-prone skin?

La Roche-Posay Mela B3 Serum is a great fit because it helps regulate oil, gently exfoliates to refine texture, and brightens skin while providing soothing hydration for blemishes. It has a safe profile with no harsh ingredients, making it well-suited for keeping oily acne-prone skin balanced and calm.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Niacinamide and capryloyl salicylic acid make this serum a great fit for your oily skin because they help gently exfoliate and refine your texture. Glycerin and dipotassium glycyrrhizate add supportive hydration and calm your blemishes.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Thermal Spring Water do for oily acne-prone skin?

Thermal spring water helps calm angry, oily skin and reduces redness, stinging, and discomfort. It is gentle enough to use alongside acne treatments to keep skin comfortable and less dry.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348993/), [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, keeping things simple and safe around sun exposure. You can use it as part of a regular routine since the ingredients help manage oil and gently refine texture.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol, but to prevent irritation it is best to apply them on alternate nights or use this serum in the morning and retinol at night. Both ingredients help refine texture and brighten skin, so spacing them out keeps your oily skin calm and smooth.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### How often should I use this serum?

Use this serum in the evening. It is a great fit for your oily acne-prone skin, providing gentle exfoliation and brightening while keeping your skin calm.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily acne-prone skin, as it contains gentle exfoliating ingredients that help keep pores clear and regulate oil. It also features soothing components that help calm blemishes with a low likelihood of causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.10 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €34.95 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €24.75 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €34.90 (https://www.amazon.it/dp/B0CM4B43DZ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €44.16 (https://www.lookfantastic.it/p/la-roche-posay-melab3-serum-intense-anti-dark-spot-serum-for-hyperpigmentation-30ml/15058248/)
Prices checked 16 Oct – 3 Nov 2026.

## Ingredients

Water, Dimethicone, Niacinamide, Glycerin, Propylene Glycol, Polysilicone-11, Silica, Bis-Peg Ppg-16 16 Peg Ppg-16 16 Dimethicone, Cystoseira Tamariscifolia Extract, 2-Mercaptonicotinoyl Glycine, Peg-20 Methyl Glucose Sesquistearate, Sodium Hyaluronate, Sodium Hydroxide, Sodium Thiosulfate, Carnosine, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Dipotassium Glycyrrhizate, Caprylic Capric Triglyceride, Capryloyl Salicylic Acid, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Xanthan Gum, Pentylene Glycol, Octyldodecanol, Retinyl Palmitate, Tocopherol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Phenoxyethanol, Ci 17200 Red 33, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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