# La Roche-Posay Hyalu B5 Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Offers excellent moisturizing for your normal skin due to sodium hyaluronate and panthenol, which hydrate and support skin barrier repair.
- While it provides general hydration beneficial for normal skin, the concentrations of sodium hyaluronate and hydrolyzed hyaluronic acid are supportive rather than targeted for wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Vitamin B5, Madecassoside, Thermal Spring Water

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its intense hydration and ability to visibly plump the skin, leading to immediate improvements in bounce and a reduction in fine dehydration lines. While many users with sensitive skin find it gentle and soothing, a significant number dislike its strong floral fragrance and sticky finish.

- Liked: Intense hydration (mostly mentioned)
- Liked: Smoothes fine lines (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Roche-Posay Hyalu B5 Serum a great fit for mature skin?

La Roche-Posay Hyalu B5 Serum is a great fit for mature skin because it offers excellent moisturizing with sodium hyaluronate and panthenol, which hydrate and support skin barrier repair. It also has an excellent safety profile with no risks of irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for mature skin?

Sodium hyaluronate and vitamin B5 make this serum a good fit by deeply hydrating and supporting your skin barrier. While these ingredients provide helpful moisture, mature skin also needs targeted ingredients like peptides or retinoids to properly smooth out wrinkles and fine lines.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Panthenol do for mature skin?

Panthenol helps mature skin by boosting hydration, smoothing dryness, and supporting the skin barrier to keep it soft and comfortable. It is unlikely to cause irritation and may help reduce the look of fine lines by improving overall moisture levels.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29577586/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine after cleansing and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated and supported while you use your retinol. Using a barrier-enhancing moisturizer alongside retinol helps improve your skin tolerance and reduces the likelihood of dryness or irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. Its ingredients help keep mature skin hydrated and are very unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores for mature skin because it has an excellent safety profile without harsh ingredients. It helps keep your skin soft and smooth while providing gentle hydration.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

This serum is safe to use on the thin skin around the eyes or on the body, as it has an excellent safety profile without harsh ingredients. Its hydrating ingredients help improve skin moisture and support barrier repair.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/it/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €27.55 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/it/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €21.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €42.99 (https://www.amazon.it/dp/B0F1G1FLGX?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €38.81 (https://www.lookfantastic.it/p/la-roche-posay-hyalu-b5-suractivated-serum-30ml/17222049/)
- Notino: €44.50 (https://www.notino.it/la-roche-posay/hyalu-b5-suractivated-serum-siero-concentrato-antirughe/p-16328156/)
Prices checked 16 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Alcohol Denat, Propylene Glycol, Panthenol, Pentylene Glycol, Dimethicone, Peg-6 Caprylic Capric Glycerides, Ppg-6-Decyltetradeceth-30, Glyceryl Isostearate, Madecassoside, Sodium Hyaluronate, Ammonium Polyacryloyldimethyl Taurate, Disodium Edta, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Citric Acid, Xanthan Gum, Butylene Glycol, Tocopherol, Phenoxyethanol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/hyalu-b5-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/hyalu-b5-serum/for/mature-skin