# La Mer The Regenerating Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [La Mer](https://lovi.care/skincare/it/brands/la-mer)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent for your normal skin, this serum utilizes yeast faex extract and saccharomyces lysate extract to promote skin renewal and improve texture, while acetyl hexapeptide-8 and dipalmitoyl hydroxyproline boost collagen production to address wrinkles and fine lines.
- Algae extract and other beneficial ingredients further support skin regeneration and overall health, making it a highly suitable choice for your skin type.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like dipotassium glycyrrhizate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Miracle Broth, Acetyl Hexapeptide-8, Niacinamide, Algae Extract, Glycerin

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Topical application of 1% Fucus vesiculosus extract gel twice daily for five weeks significantly decreased skin thickness and improved elasticity in human cheek skin compared with controls. ([Journal of Cosmetic Science, 2002](https://pubmed.ncbi.nlm.nih.gov/11917251/))
- A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells. ([Annals of the New York Academy of Sciences, 2004](https://pubmed.ncbi.nlm.nih.gov/15247018/))
- Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29745467/))
- Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation. ([Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/36135751/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Users with dry, mature, or sensitive skin frequently praise this serum for its immediate soothing and plumping effects, often noting a visible improvement in skin texture and radiance. Many experience hydration and a reduction in fine lines, though a significant portion of reviewers feel the anti-aging results do not justify the extremely high price point compared to other market alternatives.

- Liked: Deeply Hydrating (mostly mentioned)
- Disliked: Extremely High Price (mostly mentioned)
- Liked: Luxurious Feel (often mentioned)
- Liked: Smooths Skin Texture (often mentioned)
- Liked: Soothing & Calming (sometimes noted)
- Disliked: Poor Pump Design (sometimes noted)
- Disliked: Caused Breakouts/Irritation (rarely noted)
- Disliked: Strong Fragrance (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes The Regenerating Serum a great fit for mature skin?

This serum is a great fit for mature skin because it uses peptides and yeast extracts to smooth fine lines, boost collagen, and help renew your skin. It is also safe and unlikely to cause irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it includes acetyl hexapeptide-8 and dipalmitoyl hydroxyproline to boost collagen and smooth out fine lines. It also uses yeast and saccharomyces lysate extracts to encourage skin renewal and improve texture, while soothing agents help keep irritation at bay.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Miracle Broth do for mature skin?

Miracle Broth helps mature skin by reducing visible signs of aging and keeping the skin smooth and soft. It supports skin strength and protects against everyday stress, though individual results may vary.
Sources: [International Journal of Cosmetic Science, 2019](https://pubmed.ncbi.nlm.nih.gov/31032993/), [Marine Drugs, 2025](https://pubmed.ncbi.nlm.nih.gov/40278278/)

### What does Argireline do for mature skin?

Argireline helps smooth out lines and makes mature skin look firmer and less rough when used twice a day. It may also help keep skin hydrated, though its penetration is naturally limited.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, though it can also be used in the morning or twice a day. Applying it at night provides extra safety around sun exposure and keeps the routine simple.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product. Because this serum contains soothing ingredients like dipotassium glycyrrhizate, it is unlikely to cause irritation when layered carefully into your routine.

### How often should I use this serum?

This serum fits into your evening routine as a treatment step. It is unlikely to irritate your skin and helps smooth fine lines when used consistently.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it has a very low risk of irritation and is free of harsh ingredients. It relies on soothing agents and nourishing extracts to support skin health gently.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, linalool, limonene, citronellol, and geraniol).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

- Amazon.it: €396.14 (https://www.amazon.it/dp/B07X7NRNCY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Algae Extract, Dimethicone, Hdi Trimethylol Hexyllactone Crosspolymer, Hydrogenated Polyisobutene, Caprylic Capric Myristic Stearic Triglyceride, Polysilicone-11, Peg-8 Dimethicone, Peg-10 Dimethicone, Yeast Faex Extrait De Levure Extract, Citrus Aurantifolia Peel Extract, Sigesbeckia Orientalis Extract, Polygonum Cuspidatum Root Extract, Saccharomyces Lysate Extract, Sesamum Indicum Seed Oil, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sesamum Indicum Seed Powder, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Vitis Vinifera Seed Extract Grape Seed Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Punica Granatum Fruit Juice, Bupleurum Falcatum Root Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Narcissus Tazetta Bulb Extract, Mimosa Tenuiflora Bark Extract, Betula Alba Bark Extract, Chlorella Vulgaris Extract, Humulus Lupulus Extract, Laureth-4, Corallina Officinalis Extract, Glycine Soja Seed Extract Soybean Seed Extract, Micrococcus Lysate, Whey Lactis Proteine Du Petit-Lait Protein, Tartaric Acid, Glycerin, Hydrolyzed Wheat Protein, Laureth-23, Butylene Glycol, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Sucrose, Coenzyme A, Acetyl Glucosamine, Caffeine, Dipalmitoyl Hydroxyproline, Linoleic Acid, Tetraacetylphytosphingosine, Alcaligenes Polysaccharides, Bifida Lysate Ferment, Pentylene Glycol, Dipotassium Glycyrrhizate, Palmitoyl Oligopeptide, Peg-8, Sorbitol, Tocopheryl Acetate, Eryngium Maritimum Extract, Sodium Hydroxide, Hydrogenated Lecithin, Hydroxypropyl Cyclodextrin, Nordihydroguaiaretic Acid, Cyclodextrin, Maltodextrin, Acetyl Hexapeptide-8, Glyceryl Polymethacrylate, Glycosaminoglycans, Gold, Tourmaline, Linolenic Acid, Silica, Ethylbisiminomethylguaiacol Manganese Chloride, Disodium Edta, Potassium Sorbate, Phenoxyethanol, Parfum, Hydroxycitronellal, Linalool, Limonene, Citronellol, Geraniol, Green 5 Ci 61570
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-mer/the-regenerating-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-mer/the-regenerating-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-mer/the-regenerating-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-mer/the-regenerating-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-mer/the-regenerating-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-mer/the-regenerating-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-mer/the-regenerating-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-mer/the-regenerating-serum/for/mature-skin