# Kiehl's Age Defender Power Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Kiehl's](https://lovi.care/skincare/it/brands/kiehl-s)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin, as Glycerin and Hydroxypalmitoyl Sphinganine support hydration and barrier repair, while Adenosine and Hydrolyzed Rice Protein help minimize fine lines.
- The formula provides general skincare benefits for wrinkles and fine lines, with ingredients like Ruscus Aculeatus Root Extract and Caffeine contributing to skin renewal.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/oily-acne-prone-skin): Low

## Key ingredients

Cupressus Sempervirens Extract, Glycerin, Dimethicone, Hydrolyzed Soy Protein, Caffeine

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Topical caffeine acts as an active cosmetic compound by preventing excessive fat accumulation through phosphodiesterase inhibition, protecting cells against UV radiation with antioxidant properties, increasing skin microcirculation, and stimulating hair growth via 5-alpha-reductase inhibition. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21564138/))
- Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects. ([Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/))
- Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid. ([AAPS PharmSciTech, 2021](https://pubmed.ncbi.nlm.nih.gov/33796955/))

## What reviewers say

This serum is highly regarded for its lightweight, fast-absorbing formula that effectively hydrates and firms men's skin. Users frequently report visible improvements in skin texture and a reduction in the appearance of forehead lines and wrinkles with consistent daily use.

- Liked: Fast absorption (mostly mentioned)
- Liked: Non-greasy feel (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused dryness (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Subtle results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Age Defender Power Serum work for mature skin?

Kiehl's Age Defender Power Serum works moderately well for mature skin, offering hydration and helping to minimize fine lines with ingredients like glycerin and adenosine. A treatment for this skin needs high-quality anti-aging ingredients, potent antioxidants, and skin-repairing components that safely target wrinkles and boost elasticity without irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Which ingredients make this serum a good fit for mature skin?

Glycerin and Hydroxypalmitoyl Sphinganine make this serum a good fit for mature skin by supporting hydration and barrier repair, while Adenosine and Hydrolyzed Rice Protein help minimize fine lines. To fit this skin type best, a treatment needs high-quality anti-aging ingredients, potent antioxidants, and skin-repairing components that safely improve firmness and moisture without irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### What does Cypress Extract do for mature skin?

Cypress extract helps keep mature skin feeling firm and fresh while supporting a clear and balanced complexion. It is unlikely to cause irritation and works well to soothe areas prone to redness.

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, though some serums can also be used in the morning or twice a day. Mature skin needs products with ingredients like glycerin and ceramides for hydration and barrier repair, alongside peptides or retinol alternatives to smooth fine lines.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help hydrate your skin, followed by your retinol. This product works well for your mature skin, though it needs extra firming peptides and deep-reaching antioxidants to give you the best results against fine lines.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### How often should I use this serum?

You can use this treatment in your evening routine, as Lovi routines suggest applying serums then for simplicity and extra safety around sun exposure. Mature skin of this type needs products packed with deeply nourishing plant oils, potent antioxidants, and firming peptides to effectively smooth fine lines and restore a plump, youthful bounce.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it has a safe profile with no harsh or prohibited ingredients that usually trigger irritation. However, because this is an average fit, mature skin often needs richer hydrating ingredients and stronger barrier-supporting components to stay soft and smooth.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum, limonene, linalool, and citral) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dimethicone, Alcohol Denat, Isononyl Isononanoate, Butylene Glycol, Ammonium Polyacryloyldimethyl Taurate, Phenoxyethanol, Pentylene Glycol, Hydrolyzed Soy Protein, Parfum, Hydroxypropyl Tetrahydropyrantriol, Propylene Glycol, Ruscus Aculeatus Root Extract, Glycine Soja Oil, Soybean Oil, Caffeine, Tocopherol, Hydrolyzed Rice Protein, Limonene, Biosaccharide Gum-1, Disodium Edta, Adenosine, T-Butyl Alcohol, Hydroxypalmitoyl Sphinganine, Cryptomeria Japonica Bud Extract, Linalool, Citral
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/kiehl-s/age-defender-power-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/kiehl-s/age-defender-power-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/kiehl-s/age-defender-power-serum/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/kiehl-s/age-defender-power-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/kiehl-s/age-defender-power-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/kiehl-s/age-defender-power-serum/for/mature-skin