# Jole Azelaic Acid 10% Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Jole](https://lovi.care/skincare/it/brands/jole)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your combination skin, as azelaic acid and niacinamide work to reduce inflammation and regulate oil production, effectively targeting your acne and blemishes.
- Glyceryl glucoside and squalane provide additional hydration and support the skin barrier, enhancing the overall comfort and efficacy for your skin type.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like bisabolol and allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Niacinamide, Squalane, Bisabolol, Allantoin

## What the research says

- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical application of glyceryl glucoside significantly increased AQP3 mRNA levels and reduced transepidermal water loss compared with vehicle-controlled areas in volunteer subjects. ([Skin Pharmacology and Physiology, 2012](https://pubmed.ncbi.nlm.nih.gov/22584263/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Azelaic acid 15% gel showed comparable efficacy to adapalene 0.1% gel in reducing lesions, severity, and Dermatology Life Quality Index in women with adult acne, with significantly lower dryness and scaling, and demonstrated superiority during maintenance compared to no further treatment. ([Journal of the European Academy of Dermatology and Venereology, 2015](https://pubmed.ncbi.nlm.nih.gov/25399481/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20642768/))
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate reduces UVB-induced PGE2, inflammatory cytokines, and mitochondrial superoxide in human epidermal keratinocytes. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38433250/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))

## What reviewers say

Users highly recommend this serum for acne-prone and sensitive skin, noting its strong effectiveness in clearing active breakouts, reducing inflammation, and fading post-acne hyperpigmentation. The lightweight formula absorbs quickly and improves overall skin texture, though a small number of users experienced temporary dryness or a brief purging phase.

- Liked: Reduces acne breakouts (mostly mentioned)
- Liked: Fades post-acne marks (often mentioned)
- Liked: Absorbs very quickly (sometimes noted)
- Liked: Calms skin redness (sometimes noted)
- Disliked: Causes mild dryness (rarely noted)
- Disliked: Faulty pump dispenser (rarely noted)
- Disliked: Initial skin purging (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Jole Jole Azelaic Acid 10% Serum a great fit for acne-prone skin?

Jole Jole Azelaic Acid 10% Serum is a great fit for acne-prone skin because azelaic acid and niacinamide calm inflammation and balance oil to help clear breakouts. Squalane and glyceryl glucoside add moisture while bisabolol and allantoin soothe the skin without causing irritation.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/)

### Which ingredients make this serum a good fit for acne-prone skin?

Azelaic acid and niacinamide make this serum a great fit because they help calm redness and keep oil in balance to tackle breakouts. Squalane and glyceryl glucoside add moisture while soothing ingredients like bisabolol and allantoin keep your skin comfortable and safe from irritation.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Skin Pharmacology and Physiology, 2012](https://pubmed.ncbi.nlm.nih.gov/22584263/)

### What does Azelaic Acid do for acne-prone skin?

Azelaic acid helps clear acne-prone skin by fighting bacteria and calming redness, while also fading dark spots left behind by breakouts. It targets multiple causes of acne at once to keep your skin smooth and even-toned.
Sources: [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26355614/), [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it in the evening keeps things simple and helps avoid extra sun sensitivity, while soothing components like bisabolol and allantoin keep your skin calm.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, but it is best to apply them on alternate nights or separate them into your morning and evening routines to avoid overloading your skin. Using them together may increase the chance of dryness or irritation, so pairing them with soothing ingredients helps keep your skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

This treatment is used in the evening once a week to start, and people who tolerate it well and see good results can carefully use it more often. Azelaic acid and niacinamide help calm breakouts and balance oil, while soothing ingredients keep the skin comfortable.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores, and any initial purging is very rare for acne-prone skin. Azelaic acid and niacinamide help calm redness and clear blemishes, while soothing ingredients keep irritation low.
Sources: [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/), [Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €37.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethoxydiglycol, Azelaic Acid, Niacinamide, Glyceryl Glucoside, Squalane, Bisabolol, Allantoin, Ammonium Acryloyldimethyltaurate Vp Copolymer, Valine, Proline, Lysine, Serine, Sorbitan Caprylate, 1,2 Propanediol, Benzoic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/jole/azelaic-acid-10-serum/for/acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
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- Saudi Arabia: https://lovi.care/skincare/sa/p/jole/azelaic-acid-10-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/jole/azelaic-acid-10-serum/for/acne-prone-skin