# Isntree TW-Real Bifida Ampoule for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Isntree](https://lovi.care/skincare/it/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- This formulation offers high suitability for your oily skin, with niacinamide and willow bark extract effectively regulating sebum and providing mild exfoliation to address acne, blemishes, and breakouts. Bifida Lysate Ferment and Beta-Glucan work synergistically to significantly enhance your skin barrier resilience.
- The inclusion of Lactobacillus Pumpkin Extract Ferment and Lactobacillus Soybean Extract Ferment further supports skin health and hydration, complementing the primary actives.
- The product demonstrates a strong safety profile, featuring soothing ingredients like Allantoin and Bifida Lysate Ferment, ensuring no irritation for your oily skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Hydrolyzed Collagen, Copper Tripeptide-1

## What the research says

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))

## What reviewers say

Based on a very large amount of data, users consistently praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without heaviness, resulting in a "glass skin" glow and smoother texture. It is highly effective for sensitive and dry skin types seeking anti-aging benefits. A small minority of users with acne-prone or very oily skin experienced minor breakouts or found the finish slightly tacky.

- Liked: Lightweight & fast absorbing (mostly mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Strengthens skin barrier (often mentioned)
- Liked: Gentle & non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Texture/finish issues (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree TW-Real Bifida Ampoule a great fit for oily acne-prone skin?

This treatment is a great fit for your oily acne-prone skin because niacinamide and willow bark extract help control oil and gently clear breakouts, while bifida lysate ferment and beta-glucan strengthen your skin barrier. It is also very safe and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Niacinamide and willow bark extract help regulate oil and gently clear breakouts, making this serum a great fit for your oily skin. Bifida Lysate Ferment and beta-glucan also work together to strengthen your skin barrier and keep it calm.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Bifida Ferment Lysate do for oily acne-prone skin?

Bifida Ferment Lysate helps calm oily acne-prone skin by strengthening your skin barrier and lowering irritation. It is unlikely to clog pores and may help keep your skin feeling smooth and balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep your skin safe around sun exposure, and soothing ingredients like allantoin and bifida lysate ferment make it unlikely to cause irritation.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first in your evening routine, followed by your retinol. This approach helps control oil and clear breakouts while keeping your skin calm, as the soothing ingredients are unlikely to cause irritation.

### How often should I use this serum?

This treatment is meant to be used in the evening for your oily acne-prone skin. It is a great fit because it helps control oil and soothe blemishes without causing irritation, while strengthening your skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts for your oily skin, as it features soothing ingredients that help keep irritation low and safety high. Willow bark extract gently exfoliates to help prevent breakouts, while a few reviewers still mention occasional breakouts.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.10 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €34.95 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €24.75 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €19.90 (https://www.amazon.it/dp/B082TWZNYB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €23.50 (https://www.notino.it/isntree/tw-real-bifida-ampoule-siero-rivitalizzante-intenso-per-la-ristrutturazione-e-tensione-intensa-della-pelle/p-16116752/)
Prices checked 15 Oct – 2 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Dipropylene Glycol, Niacinamide, Glycerin, Lactobacillus Pumpkin Extract Ferment, Lactobacillus Soybean Extract Ferment, Rice Ferment Filtrate Sake Ferment Filtrate, Sodium Hyaluronate, Hydrolyzed Collagen, Willow Bark Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Portulaca Oleracea Extract, Chamaecyparis Obtusa Leaf Extract, Beta-Glucan, Palmitoyl Oligopeptide, Copper Tripeptide-1, Acetyl Hexapeptide-8, Allantoin, Hydroxyethylcellulose, Panthenol, Carbomer, Arginine, Butylene Glycol, Scutellaria Baicalensis Root Extract, Illicium Verum Fruit Extract Anise Fruit Extract, Adenosine, 1,2-Hexanediol, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- United Kingdom: https://lovi.care/skincare/uk/p/isntree/tw-real-bifida-ampoule/for/oily-acne-prone-skin
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